2-amino-2-phenyl-propanoic acid

Base Information

• Chemical Name: 2-amino-2-phenyl-propanoic acid
• CAS No.: 6945-32-0
• Molecular Formula: C9H11NO2
• Molecular Weight: 0
• Hs Code.: 2922499990
• Mol file: 6945-32-0.mol

Synonyms:2-amino-2-phenyl-propanoic acid

Chemical Property of 2-amino-2-phenyl-propanoic acid

Chemical Property:

• Vapor Pressure: 0.000567mmHg at 25°C
• Boiling Point: 298.5°C at 760 mmHg
• Flash Point: 134.3°C
• PSA: 63.32000
• Density: 1.197g/cm³
• LogP: 1.64540

Purity/Quality:

97% ^*data from raw suppliers

2-amino-2-phenyl-propanoicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-2-phenyl-propanoic acid

There total 114 articles about 2-amino-2-phenyl-propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + 5-methyl-5-phenylimidazolidin-2,4-dione (6843-49-8,27539-12-4,99571-24-1,101693-73-6) → (S)-2-methyl-2-phenylglycine (13398-26-0,6945-32-0)

Guidance literature:

(R)-1-phenyl-ethyl-amine; 5-methyl-5-phenylimidazolidin-2,4-dione; With sodium hydroxide; In methanol; water; at 55 ℃; for 0.5h;

With water; at 160 ℃; for 4h;

With hydrogenchloride; In water; at 25 ℃; Product distribution / selectivity;

Reference yield: 97.0%

5-methyl-5-phenylimidazolidin-2,4-dione (6843-49-8,27539-12-4,99571-24-1,101693-73-6) → (S)-2-methyl-2-phenylglycine (13398-26-0,6945-32-0)

Guidance literature:

5-methyl-5-phenylimidazolidin-2,4-dione; With sodium hydroxide; (R)-1-phenyl-ethyl-amine; In ethanol; water; at 50 ℃; for 1.5h;

With water; at 140 ℃; for 4h;

With hydrogenchloride; In water; at 25 ℃; Product distribution / selectivity;

Reference yield: 90.8%

(S)-2-Benzoylamino-2-phenyl-propionic acid methyl ester (169566-73-8) → (S)-2-methyl-2-phenylglycine (13398-26-0,6945-32-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 12h;

DOI:10.1002/hlca.19950780305

upstream raw materials:

sodium cyanide

acetophenone

α-amino-α-methylphenylacetonitrile

5-methyl-5-phenylimidazolidin-2,4-dione

Downstream raw materials:

β-oxy-α.β.β-triphenyl-isopropylamine

p-Phenylazo-benzyloxycarbonyl-DL-α-phenyl-alanin

2-[6-(3-chloro-phenyl)-pyrazin-2-ylamino]-2-phenyl-propan-1-ol

(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

Refernces

• 1、 Leonard, Daniel J.,Ward, John W.,Clayden, Jonathan. "Asymmetric α-arylation of amino acids". . p. 105 - 109. Retrieved 2018/10/15.
• 2、 -. "UNNATURAL AMINO ACIDS". Paragraph 00190; 00296. . Retrieved 2018/07/05.