2-amino-2-phenylpropanenitrile

Base Information

• Chemical Name: 2-amino-2-phenylpropanenitrile
• CAS No.: 4355-46-8
• Molecular Formula: C9H10N2
• Molecular Weight: 146.192
• Hs Code.: 2926909090
• Mol file: 4355-46-8.mol

Synonyms:2-amino-2-phenylpropionitrile;2-Amino-2-phenyl-propionitril;2-amino-2-phenylpropanenitrile;2-phenyl-2-aminopropanenitrile;

Chemical Property of 2-amino-2-phenylpropanenitrile

Chemical Property:

• PSA: 49.81000
• LogP: 2.08438

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-2-phenylpropanenitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-2-phenylpropanenitrile

There total 9 articles about 2-amino-2-phenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

potassium cyanide (151-50-8) + acetophenone (98-86-2) → α-amino-α-methylphenylacetonitrile (4355-46-8)

Guidance literature:

With aluminum oxide; ammonium chloride; In acetonitrile; at 50 ℃; for 48h; ultrasound;

DOI:10.1246/cl.1987.687

Reference yield: 64.0%

2-hydroxy-2-phenylpropionitrile (20102-12-9) → α-amino-α-methylphenylacetonitrile (4355-46-8)

Guidance literature:

With titanium(IV) isopropylate; ammonia; benzoic acid; In methanol; tert-butyl methyl ether; at 60 ℃; for 18h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior;

DOI:10.1021/acs.orglett.9b03194

Reference yield: 30.0%

C14H17NO3 → α-amino-α-methylphenylacetonitrile (4355-46-8)

Guidance literature:

With titanium(IV) isopropylate; ammonia; benzoic acid; In methanol; tert-butyl methyl ether; at 60 ℃;

DOI:10.1021/acs.orglett.9b03194

upstream raw materials:

2-hydroxy-2-phenylpropionitrile

potassium cyanide

acetophenone

hydrogen cyanide

Downstream raw materials:

2-Acetamino-2-methyl-phenylessigsaeure-nitril

DL-α-methylphenylglycine amide

2-amino-2-phenylpropanoic acid

benzoic acid