Carbamic acid, (2-chloro-6-methoxyphenyl)-, ethyl ester

Base Information

• Chemical Name: Carbamic acid, (2-chloro-6-methoxyphenyl)-, ethyl ester
• CAS No.: 172217-13-9
• Molecular Formula: C₁₀H₁₂ClNO₃
• Molecular Weight: 229.663
• DSSTox Substance ID: DTXSID201205287
• Mol file: 172217-13-9.mol

Synonyms:DTXSID201205287;Carbamic acid, (2-chloro-6-methoxyphenyl)-, ethyl ester;172217-13-9

Chemical Property of Carbamic acid, (2-chloro-6-methoxyphenyl)-, ethyl ester

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 229.0505709
• Heavy Atom Count: 15
• Complexity: 213

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)NC1=C(C=CC=C1Cl)OC

Technology Process of Carbamic acid, (2-chloro-6-methoxyphenyl)-, ethyl ester

There total 6 articles about Carbamic acid, (2-chloro-6-methoxyphenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-methoxybenzoic acid (3260-89-7) → ethyl 6-chloro-2-methoxycarbanilate (172217-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoroazidate, Et₃N / dioxane / 0.5 h / Ambient temperature

2: 2 h / Heating

With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane;

DOI:10.1248/cpb.43.1287

Reference yield:

ethyl 2-chloro-6-nitrobenzoate (172217-16-2) → ethyl 6-chloro-2-methoxycarbanilate (172217-13-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / 25percent aq. TiCl₃, AcOH / 0.15 h / Ambient temperature

2: 1.) aq. NaNO₂, H₂SO₄ / 2.) 120 deg C, 1 h

3: 81 percent / K₂CO₃ / acetone / 3.5 h / Heating

4: 98 percent / 10percent aq. KOH / 3 h / Heating

5: diphenyl phosphoroazidate, Et₃N / dioxane / 0.5 h / Ambient temperature

6: 2 h / Heating

With potassium hydroxide; titanium(III) chloride; sulfuric acid; diphenyl phosphoryl azide; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In 1,4-dioxane; acetone;

DOI:10.1248/cpb.43.1287

Reference yield:

ethyl 2-chloro-6-hydroxybenzoate (112270-06-1) → ethyl 6-chloro-2-methoxycarbanilate (172217-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / K₂CO₃ / acetone / 3.5 h / Heating

2: 98 percent / 10percent aq. KOH / 3 h / Heating

3: diphenyl phosphoroazidate, Et₃N / dioxane / 0.5 h / Ambient temperature

4: 2 h / Heating

With potassium hydroxide; diphenyl phosphoryl azide; potassium carbonate; triethylamine; In 1,4-dioxane; acetone;

DOI:10.1248/cpb.43.1287

upstream raw materials:

ethanol

2-chloro-6-methoxybenzoic acid

ethyl 2-chloro-6-nitrobenzoate

ethyl 2-chloro-6-hydroxybenzoate

Downstream raw materials:

6-chloro-o-anisidine