2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Chemical Name:2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide
CAS No.:1195764-74-9
Molecular Formula:C₂₅H₂₄F₃N₅O₄S₃
Molecular Weight:611.69
Hs Code.:

2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Chemical Property of 2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Technology Process of 2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

There total 10 articles about 2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1195764-74-9
2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:

Reference yield:

: 49773-20-8
2-Methanesulfonyl-ethylamine

: 1195768-43-4
N-{5-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

: 1195764-74-9
2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: With hydrogenchloride; In 2,2,2-trifluoroethanol; at 180 ℃; Microwave irradiation;
DOI:10.1021/ml4000063

Reference yield:

: 1007-16-5
3-bromo-4-fluorobenzoic acid

: 1195764-74-9
2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid / 1 h / Reflux

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: pyridine / dichloromethane / 20 °C

5: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

6: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C

7: N,N-dimethyl acetamide / 20 - 60 °C

8: N,N-dimethyl acetamide / 60 - 80 °C

9: hydrogenchloride / 2,2,2-trifluoroethanol / 180 °C / Microwave irradiation

With pyridine; hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; N-Bromosuccinimide; sulfuric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; N,N-dimethyl acetamide;
DOI:10.1021/ml4000063