49773-20-8Relevant articles and documents
A method for synthesizing pulls the handkerchief for the Nepali side chain
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Paragraph 0031, (2017/04/08)
The invention discloses a synthetic method of lapatinib side chain, belongs to the field of synthesis of medicines and solves problems that synthesis of the lapatinib side chain in the prior art is expensive in raw materials and long in a synthetic line so that a large-scale production of the lapatinib side chain is high in difficulty. The method particularly includes following steps: carrying out a reaction between methylsulfonyl ethanol and methylsulfonyl chloride or methylsulfonyl ethanol and 4-toluene sulfonyl chloride to generate a compound methanesulfonate methylsulfonyl ethyl ester, and enabling the methanesulfonate methylsulfonyl ethyl ester to react with ammonia to obtain the lapatinib side chain. The synthetic method is low in cost of raw materials, is short in synthesis line and is easy to carry out in large-scale production.
SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
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Page/Page column 324, (2012/09/21)
The present invention relates to substituted 6,5 -fused bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof.
PHARMACEUTICAL USE OF SUBSTITUTED AMIDES
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Page/Page column 40, (2009/05/28)
The use of substituted amides for modulating the activity of 11-hydroxysteroid dehydrogenase type 1 (11HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.