4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester

Base Information

• Chemical Name: 4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester
• CAS No.: 99392-84-4
• Molecular Formula: C₂₂H₃₀O₇
• Molecular Weight: 406.476
• Mol file: 99392-84-4.mol

Synonyms:

Chemical Property of 4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester

There total 3 articles about 4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-carboxy-3-hydroxyphenyl)acetic acid (42421-12-5) → 4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester (99392-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.32 g / potassium carbonate / acetone / 3 h / Heating

2: 2.30 g / conc. sulphuric acid / 3 h / Heating

3: 1) LDA / 1) hexane, -78 deg C, 2) room temp., 20 h

With sulfuric acid; potassium carbonate; lithium diisopropyl amide; In acetone;

Reference yield:

2-carboxy-3-methoxybenzene-1-acetic acid (1137-31-1) → 4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester (99392-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.30 g / conc. sulphuric acid / 3 h / Heating

2: 1) LDA / 1) hexane, -78 deg C, 2) room temp., 20 h

With sulfuric acid; lithium diisopropyl amide;

Reference yield:

acetic acid tert-butyl ester (540-88-5) + methyl (2-carbomethoxy-3-methoxyphenyl)acetate (1214-87-5) → 4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester (99392-84-4)

Guidance literature:

With lithium diisopropyl amide; Multistep reaction; 1) hexane, -78 deg C, 2) room temp., 20 h;

upstream raw materials:

acetic acid tert-butyl ester

methyl (2-carbomethoxy-3-methoxyphenyl)acetate

(2-carboxy-3-hydroxyphenyl)acetic acid

2-carboxy-3-methoxybenzene-1-acetic acid

Refernces