2-Carboxy-3-methoxybenzeneacetic acid

Base Information

• Chemical Name: 2-Carboxy-3-methoxybenzeneacetic acid
• CAS No.: 1137-31-1
• Molecular Formula: C10H10O5
• Molecular Weight: 210.186
• Mol file: 1137-31-1.mol

Synonyms:2-Carboxy-3-methoxybenzeneacetic acid

Chemical Property of 2-Carboxy-3-methoxybenzeneacetic acid

Chemical Property:

• Melting Point: 165-166 °C
• Boiling Point: 411.0±30.0 °C(Predicted)
• PKA: 3.65±0.36(Predicted)
• PSA: 83.83000
• Density: 1.370±0.06 g/cm3(Predicted)
• LogP: 1.02050

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Carboxy-3-methoxybenzeneacetic acid

There total 9 articles about 2-Carboxy-3-methoxybenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methoxy-6-methyl-benzoic acid (6161-65-5) → 2-carboxy-3-methoxybenzene-1-acetic acid (1137-31-1)

Guidance literature:

DOI:10.1016/S0040-4020(01)81434-4

Reference yield: 73.0%

methyl 2-hydroxy-6-(methoxycarbonylmethyl)benzoate (43071-26-7) + dimethyl sulfate (77-78-1) → 2-carboxy-3-methoxybenzene-1-acetic acid (1137-31-1)

Guidance literature:

With sodium hydroxide; In diethyl ether; acetone; for 3h; Ambient temperature;

Reference yield:

ethyl 2-hydroxy-6-methylbenzoate (6555-40-4) → 2-carboxy-3-methoxybenzene-1-acetic acid (1137-31-1)

Guidance literature:

Multi-step reaction with 3 steps

3: 95 percent

DOI:10.1016/S0040-4020(01)81434-4

upstream raw materials:

2-methoxy-6-methyl-benzoic acid

(2-carboxy-3-hydroxyphenyl)acetic acid

dimethyl sulfate

methyl 2-hydroxy-6-(methoxycarbonylmethyl)benzoate

Downstream raw materials:

3'-Deoxythunberginol A

4-[2-(2-tert-Butoxycarbonyl-acetyl)-3-methoxy-phenyl]-3-oxo-butyric acid tert-butyl ester

3-(4-methoxyphenyl)-7-methoxy-2-benzopyran-1(1H)-one

6-Methoxy-2-(methoxycarbonylmethyl)benzoic acid

Refernces

• 1、 Hauser,Rhee. "". . p. 245. Retrieved 1977.
• 2、 Yamaguchi, Masahiko,Hasebe, Koichi,Uchida, Minoru,Irie, Akemi,Minami, Toru. "A BIOMIMETIC SYNTHESIS OF POLICYCLIC QUINONES". . p. 2017 - 2020. Retrieved 2007/10/02.
• 3、 Tamura, Yasumitsu,Fukata, Fumio,Tsugoshi, Teruhisa,Sasho, Manabu,Nakajima, Yuko,Kita, Yasuyuki. "Synthesis of 8-Methoxy- and 8-Methoxy-6-methylhomophthalic Anhydrides, Key Intermediates for the Synthesis of Anthracyclinones and peri-Hydroxylated Polycyclic Aromatic Compounds". . p. 3259 - 3262. Retrieved 2007/10/02.