2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID
• CAS No.: 57743-13-2
• Molecular Formula: C₁₄H₉NO₂
• Molecular Weight: 223.231
• Mol file: 57743-13-2.mol

Synonyms:2-Biphenylcarboxylicacid, 2'-cyano- (6CI); 2'-Cyanobiphenyl-2-carboxylic acid; NSC 28066

Chemical Property of 2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 170-172 °C
• Boiling Point: 427.6°Cat760mmHg
• PKA: 3.68±0.36(Predicted)
• Flash Point: 212.4°C
• PSA: 61.09000
• Density: 1.3g/cm³
• LogP: 2.92348

Purity/Quality:

≥98% ^*data from raw suppliers

2-(2-cyanophenyl)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID

There total 21 articles about 2''-CYANO-1,1''-BIPHENYL-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

phenanthrene-9,10-dione oxime (14140-04-6) → 2'-cyano-[1,1'-biphenyl]-2-carboxylic acid (57743-13-2)

Guidance literature:

With calcium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; water; p-toluenesulfonyl chloride; In toluene; for 2h; Heating;

Reference yield: 89.0%

9-hydroxy-10-nitroso-phenanthrene (96794-13-7) → 2'-cyano-[1,1'-biphenyl]-2-carboxylic acid (57743-13-2)

Guidance literature:

With sodium hydroxide; benzenesulfonyl chloride; In 1,4-dioxane; water; for 0.25h; Heating;

DOI:10.1007/BF00633506

Reference yield: 87.2%

O-(2'-cyano-2-biphenylylcarbonyl)-9,10-phenathrenequinone oxime (120007-29-6) → 2'-cyano-[1,1'-biphenyl]-2-carboxylic acid (57743-13-2)

Guidance literature:

With calcium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; water; p-toluenesulfonyl chloride; In toluene; for 2h; Heating;

upstream raw materials:

pyridine

phenanthrene-9,10-dione oxime

benzenesulfonyl chloride

2-carboxy-2'-(aminocarboxyl)-1,1'-biphenyl

Downstream raw materials:

10-Hydroxy-phenanthridin-1-carbonsaeurelacton

2'-aminomethylbiphenyl-2-carboxylic acid