Technology Process of 25,26-dimethoxy-9,23-dimethyl-27-nitro-4-phenyl-13,16,19-trioxatetracyclo<19.3.1.12,6.17,11>heptacosa-1-(25),2,4,6(27),7,9,11(26),21,23-nonaene
There total 6 articles about 25,26-dimethoxy-9,23-dimethyl-27-nitro-4-phenyl-13,16,19-trioxatetracyclo<19.3.1.12,6.17,11>heptacosa-1-(25),2,4,6(27),7,9,11(26),21,23-nonaene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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108294-08-2
25,26-dimethoxy-9,23-dimethyl-27-nitro-4-phenyl-13,16,19-trioxatetracyclo<19.3.1.12,6.17,11>heptacosa-1-(25),2,4,6(27),7,9,11(26),21,23-nonaene
- Guidance literature:
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With
sodium hydride;
In
tetrahydrofuran;
for 8h;
Heating;
DOI:10.1021/jo00388a018
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108294-08-2
25,26-dimethoxy-9,23-dimethyl-27-nitro-4-phenyl-13,16,19-trioxatetracyclo<19.3.1.12,6.17,11>heptacosa-1-(25),2,4,6(27),7,9,11(26),21,23-nonaene
- Guidance literature:
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Multi-step reaction with 6 steps
1: 20 percent / boron trifluoride etherate / 2 h / 70 °C
2: 90 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 0.75 h / Heating
3: 56 percent / hexamethylenetetramine / 96 h / 80 - 90 °C
4: 78 percent / sodium borohydride / methanol / 1.) 20 min, 2.) RT, 30 min
5: 80 percent / phosphorus tribromide / benzene / 16 h / Ambient temperature
6: 23 percent / sodium hydride / tetrahydrofuran / 8 h / Heating
With
sodium tetrahydroborate; hexamethylenetetramine; boron trifluoride diethyl etherate; potassium tert-butylate; phosphorus tribromide; sodium hydride;
In
tetrahydrofuran; methanol; tert-butyl alcohol; benzene;
DOI:10.1021/jo00388a018
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108294-08-2
25,26-dimethoxy-9,23-dimethyl-27-nitro-4-phenyl-13,16,19-trioxatetracyclo<19.3.1.12,6.17,11>heptacosa-1-(25),2,4,6(27),7,9,11(26),21,23-nonaene
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 56 percent / hexamethylenetetramine / 96 h / 80 - 90 °C
2: 78 percent / sodium borohydride / methanol / 1.) 20 min, 2.) RT, 30 min
3: 80 percent / phosphorus tribromide / benzene / 16 h / Ambient temperature
4: 23 percent / sodium hydride / tetrahydrofuran / 8 h / Heating
With
sodium tetrahydroborate; hexamethylenetetramine; phosphorus tribromide; sodium hydride;
In
tetrahydrofuran; methanol; benzene;
DOI:10.1021/jo00388a018
