9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine

Base Information

Chemical Name:9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine
CAS No.:145215-29-8
Molecular Formula:C₂₄H₂₅N₅O₃
Molecular Weight:431.494
Hs Code.:

Synonyms:

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Chemical Property of 9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine

Chemical Property:

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Technology Process of 9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine

There total 11 articles about 9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145215-26-5
N-[9-(2,2-Bis-benzyloxymethyl-cyclopropyl)-6-chloro-9H-purin-2-yl]-formamide

: 145215-29-8
9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine

Guidance literature:: With formic acid; at 100 ℃; for 2.5h; Yield given;
DOI:10.1039/P19920002519

Reference yield:

: 27441-79-8
2-methylenepropane-1,3-bisbenzyl ether

: 145215-29-8
9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine

Guidance literature:: Multi-step reaction with 9 steps

1: 56.2 percent / cupric sulfate / 0.5 h / 90 °C

2: 84.7 percent / KOH / methanol / Ambient temperature

3: 1.) ClCO₂Et, Et₃N, 2.) NaN₃ / 1.) acetone, 0 deg C, 1 h, 2.) H₂O, room temperature, 1 h

4: 12.8 g / toluene / 1 h / 90 - 100 °C

5: 84.8 percent / 48 h / 90 - 100 °C

6: 100 percent / CF₃CO₂H / 0.33 h / Ambient temperature

7: 90.7 percent / diisopropylethylamine / dioxane / 1.) room temperature, 7 h, 2.) 70 deg C, 2 h

8: 84.64 mg / HC(OEt)3, hydrochloric acid / dimethylformamide / 72 h / 40 °C

9: 80percent HCO₂H / 2.5 h / 100 °C

With hydrogenchloride; potassium hydroxide; formic acid; sodium azide; chloroformic acid ethyl ester; copper(II) sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; orthoformic acid triethyl ester; trifluoroacetic acid; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1039/P19920002519

Reference yield:

: 116477-30-6
4,6-dichloro-2,5-diformamido-pyrimidine

: 145215-29-8
9-<2,2-bis(benzyloxymethyl)cyclopropyl>guanine

Guidance literature:: Multi-step reaction with 3 steps

1: 90.7 percent / diisopropylethylamine / dioxane / 1.) room temperature, 7 h, 2.) 70 deg C, 2 h

2: 84.64 mg / HC(OEt)3, hydrochloric acid / dimethylformamide / 72 h / 40 °C

3: 80percent HCO₂H / 2.5 h / 100 °C

With hydrogenchloride; formic acid; N-ethyl-N,N-diisopropylamine; orthoformic acid triethyl ester; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1039/P19920002519