Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester
• CAS No.: 104655-83-6
• Molecular Formula: C₄₄H₅₁N₄O₁₀P
• Molecular Weight: 826.883
• Mol file: 104655-83-6.mol

Synonyms:

Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester

There total 4 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester (104655-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dioxane / 0.5 h

2: 0.25 g / tetrazole / acetonitrile

With 1H-tetrazole; triethylamine; In 1,4-dioxane; acetonitrile; 1: Substitution / 2: Substitution;

DOI:10.1007/BF02786343

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester (104655-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dioxane / 0.5 h

2: 0.25 g / tetrazole / acetonitrile

With 1H-tetrazole; triethylamine; In 1,4-dioxane; acetonitrile; 1: Substitution / 2: Substitution;

DOI:10.1007/BF02786343

Reference yield:

2-Nitrobenzyl alcohol (612-25-9) + 5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite (104655-84-7) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-nitro-benzyl ester (104655-83-6)

Guidance literature:

With 1H-tetrazole; In acetonitrile;

DOI:10.1007/BF02786343

upstream raw materials:

2-Nitrobenzyl alcohol

bis(diisopropylamino)chlorophosphine

5'-O-(4-4'-dimethoxytrityl)thymidine

5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite