[4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate

Base Information

Chemical Name:[4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate
CAS No.:888973-04-4
Molecular Formula:C₂HF₃O₂*C₁₈H₂₇ClN₂O₃
Molecular Weight:468.901
Hs Code.:

Synonyms:

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Chemical Property of [4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate

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Technology Process of [4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate

There total 4 articles about [4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888972-27-8
(4-chloro-2-formylphenoxy)acetic acid 1,1-dimethylethyl ester

: 888973-04-4
[4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / tetrahydrofuran / 20 h / 18 - 25 °C / Inert atmosphere

1.2: 20 h / Inert atmosphere

2.1: dichloromethane / Inert atmosphere

With magnesium sulfate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm1014549

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 888973-04-4
[4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

2.1: magnesium sulfate / tetrahydrofuran / 20 h / 18 - 25 °C / Inert atmosphere

2.2: 20 h / Inert atmosphere

3.1: dichloromethane / Inert atmosphere

With magnesium sulfate; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1014549

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 888973-04-4
[4-chloro-2-[[(3S)-3-methyl-1-piperazinyl]methyl]phenoxy]acetic acid 1,1-dimethylethyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

2.1: magnesium sulfate / tetrahydrofuran / 20 h / 18 - 25 °C / Inert atmosphere

2.2: 20 h / Inert atmosphere

3.1: dichloromethane / Inert atmosphere

With magnesium sulfate; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1014549