C₁₈H₂₂N₄S*ClH

Base Information

• Chemical Name: C₁₈H₂₂N₄S*ClH
• CAS No.: 1567843-34-8
• Molecular Formula: C₁₈H₂₂N₄S*ClH
• Molecular Weight: 362.926
• Mol file: 1567843-34-8.mol

Synonyms:

Chemical Property of C₁₈H₂₂N₄S*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₂N₄S*ClH

There total 8 articles about C₁₈H₂₂N₄S*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H22N4S*C2HF3O2 → C18H22N4S*ClH (1567843-34-8)

Guidance literature:

With hydrogenchloride; sodium chloride; In chloroform; water; at 20 ℃;

DOI:10.1016/j.bmcl.2014.01.021

Reference yield:

4-iodopyridine (15854-87-2) → C18H22N4S*ClH (1567843-34-8)

Guidance literature:

Multi-step reaction with 9 steps

1: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / 60 °C

2: hydrogen; palladium on activated charcoal; acetic acid / methanol / 20 °C

3: Dess-Martin periodane / dichloromethane / 20 °C

4: tetrahydrofuran / 0 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

6: hydrazine; water / methanol / 20 °C

7: triethylamine / N,N-dimethyl-formamide / 20 °C

8: dichloromethane / 20 °C

9: hydrogenchloride; sodium chloride / chloroform; water / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; di-isopropyl azodicarboxylate; palladium on activated charcoal; water; hydrogen; Dess-Martin periodane; acetic acid; triethylamine; triphenylphosphine; sodium chloride; hydrazine; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 4: |Grignard Reaction;

DOI:10.1016/j.bmcl.2014.01.021

Reference yield:

4-(3-Hydroxypropyl)pyridine (2629-72-3) → C18H22N4S*ClH (1567843-34-8)

Guidance literature:

Multi-step reaction with 7 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: tetrahydrofuran / 0 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

4: hydrazine; water / methanol / 20 °C

5: triethylamine / N,N-dimethyl-formamide / 20 °C

6: dichloromethane / 20 °C

7: hydrogenchloride; sodium chloride / chloroform; water / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; water; Dess-Martin periodane; triethylamine; triphenylphosphine; sodium chloride; hydrazine; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 2: |Grignard Reaction;

DOI:10.1016/j.bmcl.2014.01.021

upstream raw materials:

4-iodopyridine

3-(pyridin-4-yl)propane-2-yn-1-ol

4-(3-Hydroxypropyl)pyridine

3-(pyridin-4-yl)propionaldehyde