dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate

Base Information

• Chemical Name: dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate
• CAS No.: 74780-66-8
• Molecular Formula: C₂₀H₁₆ClNO₆
• Molecular Weight: 401.803

Synonyms:

Chemical Property of dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate

There total 4 articles about dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.7%

1--3-oxidopyridinium (74780-48-6) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate (74780-66-8)

Guidance literature:

With hydroquinone; In acetonitrile; at 50 - 60 ℃; for 4h;

DOI:10.1039/P19800000362

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) → dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate (74780-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95.7 percent / tetrahydrofuran / 3 h / 20 °C

2: 94 percent / NEt₃ / acetonitrile

3: 18.7 percent / hydroquinone / acetonitrile / 4 h / 50 - 60 °C

With triethylamine; hydroquinone; In tetrahydrofuran; acetonitrile;

DOI:10.1039/P19800000362

Reference yield:

trans-1-(4-chlorophenyl)-3-chloroprop-2-en-1-one (15724-88-6) → dimethyl 8--2-oxo-8-azabicyclo<3.2.1>octa-3,6-diene-6,7-dicarboxylate (74780-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95.7 percent / tetrahydrofuran / 3 h / 20 °C

2: 94 percent / NEt₃ / acetonitrile

3: 18.7 percent / hydroquinone / acetonitrile / 4 h / 50 - 60 °C

With triethylamine; hydroquinone; In tetrahydrofuran; acetonitrile;

DOI:10.1039/P19800000362

upstream raw materials:

1--3-oxidopyridinium

dimethyl acetylenedicarboxylate

3-HYDROXYPYRIDINE

trans-1-(4-chlorophenyl)-3-chloroprop-2-en-1-one

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