ethyl 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

Chemical Name:ethyl 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS No.:309267-51-4
Molecular Formula:C₂₃H₂₁ClN₄O₂S
Molecular Weight:452.964
Hs Code.:
Mol file:309267-51-4.mol

Synonyms:

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Chemical Property of ethyl 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

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Technology Process of ethyl 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 4 articles about ethyl 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 141-97-9
ethyl acetoacetate

: 17356-08-0
thiourea

: 36663-00-0
1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde

: 309267-51-4
ethyl 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate

Guidance literature:: With zinc(II) chloride; at 20 ℃; Milling; Green chemistry;

Reference yield:

: 100-63-0
phenylhydrazine

: 309267-51-4
ethyl 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 0.25 h / 25 °C

2: trichlorophosphate / 2 h / 0 - 90 °C

3: toluene-4-sulfonic acid / ethanol / 7 h / Reflux

With toluene-4-sulfonic acid; acetic acid; trichlorophosphate; In ethanol; 3: Biginelli reaction;
DOI:10.1016/j.bmcl.2012.02.101

Reference yield:

: 57845-08-6
p-chloroacetophenone phenylhydrazone

: 309267-51-4
ethyl 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / 0 - 90 °C

2: toluene-4-sulfonic acid / ethanol / 7 h / Reflux

With toluene-4-sulfonic acid; trichlorophosphate; In ethanol; 2: Biginelli reaction;
DOI:10.1016/j.bmcl.2012.02.101