1-(5'-hydroxyhexylcarbamoyl)-5-fluorouracil

Base Information

Chemical Name:1-(5'-hydroxyhexylcarbamoyl)-5-fluorouracil
CAS No.:74173-52-7
Molecular Formula:C₁₁H₁₆FN₃O₄
Molecular Weight:273.264
Hs Code.:
Mol file:74173-52-7.mol

Synonyms:1-(5-Hydroxyhexylcarbamoyl)-5-fluorouracil;1-(5'-Hydroxyhexylcarbamoyl)-5-fluorouracil

Suppliers and Price of 1-(5'-hydroxyhexylcarbamoyl)-5-fluorouracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 1-(5'-hydroxyhexylcarbamoyl)-5-fluorouracil

Chemical Property:

PSA：107.94000
Density:1.35g/cm³
LogP:0.40120

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1-(5'-hydroxyhexylcarbamoyl)-5-fluorouracil

There total 5 articles about 1-(5'-hydroxyhexylcarbamoyl)-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.7%

: 74173-51-6
1-(5-oxohexylcarbamoyl)-5-fluorouracil

: 74173-52-7
1-(5-hydroxyhexylcarbamoyl)-5-fluorouracil

Guidance literature:: With sodium tetrahydroborate; In methanol; at 5 - 10 ℃; for 1.5h;
DOI:10.1248/cpb.34.893

Reference yield:

: 5100-36-7
6-isocyanato-hexanoic acid ethyl ester

: 74173-52-7
1-(5-hydroxyhexylcarbamoyl)-5-fluorouracil

Guidance literature:: Multi-step reaction with 4 steps

1: 90.9 percent / pyridine / 3 h / 90 °C

2: 48.8 percent / 1.) pyridine, triethylamine / 1.) 5 deg C, 30 min.; 2.) 20 deg C, 30 min.

3: 51.1 percent / conc. HCl / methanol / 14 h / 30 °C

4: 43.7 percent / NaBH₄ / methanol / 1.5 h / 5 - 10 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; triethylamine; In methanol;
DOI:10.1248/cpb.34.893

Reference yield:

: 3633-17-8
ethyl 6-aminocaproate hydrochloride

: 74173-52-7
1-(5-hydroxyhexylcarbamoyl)-5-fluorouracil

Guidance literature:: Multi-step reaction with 5 steps

1: 72.94 percent / toluene / 2 h / 60 - 110 °C

2: 90.9 percent / pyridine / 3 h / 90 °C

3: 48.8 percent / 1.) pyridine, triethylamine / 1.) 5 deg C, 30 min.; 2.) 20 deg C, 30 min.

4: 51.1 percent / conc. HCl / methanol / 14 h / 30 °C

5: 43.7 percent / NaBH₄ / methanol / 1.5 h / 5 - 10 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; triethylamine; In methanol; toluene;
DOI:10.1248/cpb.34.893