5-bromo-7-fluoroquinoxaline

Base Information

• Chemical Name: 5-bromo-7-fluoroquinoxaline
• CAS No.: 1628908-19-9
• Molecular Formula: C₈H₄BrFN₂
• Molecular Weight: 227.036
• Mol file: 1628908-19-9.mol

Synonyms:

Chemical Property of 5-bromo-7-fluoroquinoxaline

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-7-fluoroquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-7-fluoroquinoxaline

There total 2 articles about 5-bromo-7-fluoroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.6%

3-bromo-5-fluoro-1,2-phenylenediamine (115440-10-3) + Glyoxal (131543-46-9,107-22-2) → 5-bromo-7-fluoroquinoxaline (1628908-19-9)

Guidance literature:

In methanol; water; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 39.0%

→ 5-bromo-7-fluoroquinoxaline (1628908-19-9)

Guidance literature:

With acetic acid; In ethanol; at 100 ℃; for 14h;

Reference yield: 41.0%

8-oxa-3-aza-bicyclo[3.2.1]octane (280-13-7) + 5-bromo-7-fluoroquinoxaline (1628908-19-9) → 3-(8-bromoquinoxalin-6-yl)-8-oxa-3-azabicyclo[3.2.1]octane

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 0.333333h; Sealed tube;

upstream raw materials:

3-bromo-5-fluoro-1,2-phenylenediamine

Glyoxal

Refernces

• 1、 -. "BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME". Paragraph 0313; 0314; 0417; 0418. . Retrieved 2018/08/07.
• 2、 -. "DNA-PK INHIBITORS". Paragraph 0139; 0140. . Retrieved 2014/09/29.