115440-10-3Relevant academic research and scientific papers
FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN
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Page/Page column 58; 64, (2021/02/12)
Provided herein are compounds that are useful in the treatment of pain in a subject. Also provided herein is a pharmaceutical composition comprising compounds or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier and methods of treating pain in a subject in need thereof.
Fluorine atom substituted benzo heterocycle based conjugated molecule material as well as preparation method and application thereof
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Paragraph 0094; 0097; 0100; 0101, (2018/07/30)
The invention discloses a fluorine atom substituted benzo heterocycle based conjugated molecule material as well as a preparation method and application thereof. The conjugated molecule material is ofan acceptor-donor-acceptor type structure, wherein an a
NOVEL COMPOUND FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
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Paragraph 0119-0121, (2016/10/10)
Provided are a compound for an organic light emitting device and an organic light emitting device comprising the same. To this end, it is possible to provide a compound for an organic light emitting device which can be used as a host, a hole-transport material, or an electron-transport material capable of enhancing light-emitting efficiency of phosphorescent light-emitting materials by having outstanding electrical stability, an electron and hole transportability, and a high level of triplet state energy, and the organic light emitting device.
SERINE/THREONINE PAK1 INHIBITORS
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Page/Page column 118, (2013/03/26)
Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.
Structure-guided design of AMP mimics that inhibit fructose-1,6- bisphosphatase with high affinity and specificity
Erion, Mark D.,Dang, Qun,Reddy, M. Rami,Kasibhatla, Srinivas Rao,Huang, Jingwei,Lipscomb, William N.,Van Poelje, Paul D.
, p. 15480 - 15490 (2008/09/19)
AMP binding sites are commonly used by nature for allosteric regulation of enzymes controlling the production and metabolism of carbohydrates and lipids. Since many of these enzymes represent potential drug targets for metabolic diseases, efforts were ini
Glycine receptor antagonists and the use thereof
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, (2008/06/13)
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia and treating psychosis are disclosed by administering to an animal in need of such treatment a compound having high affinity for the glycine binding site, lacking PCP side effects and which crosses the blood brain barrier of the animal. Also disclosed are novel 1,4-dihydroquinoxaline-2,3-diones, and pharmaceutical compositions thereof. Also disclosed are highly soluble ammonium salts of 1,4-dihydroquinoxaline-2,3-diones.
