2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon

Base Information

• Chemical Name: 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon
• CAS No.: 34810-60-1
• Molecular Formula: C₂₇H₂₈O₉
• Molecular Weight: 496.514
• Mol file: 34810-60-1.mol

Synonyms:

Chemical Property of 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon

There total 6 articles about 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-methoxy-4-benzyloxybenzoyl chloride (1486-52-8) + 2-hydroxy-3,4,5,6-tetramethoxyacetophenone (3162-28-5) → 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon (34810-60-1)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2011.05.121

Reference yield:

1-(2,3,4,5,6-pentamethoxyphenyl)ethan-1-one (14786-40-4) → 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon (34810-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trichloride / dichloromethane / 3 h / -78 - -15 °C

2: triethylamine / dichloromethane

With boron trichloride; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2011.05.121

Reference yield:

2,3,4,5,6-pentamethoxybenzoic acid (91556-09-1) → 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon (34810-60-1)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

2: iron(III)-acetylacetonate / tetrahydrofuran / 0 - 20 °C

3: boron trichloride / dichloromethane / 3 h / -78 - -15 °C

4: triethylamine / dichloromethane

With oxalyl dichloride; iron(III)-acetylacetonate; boron trichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2011.05.121

upstream raw materials:

3-methoxy-4-benzyloxybenzoyl chloride

2-hydroxy-3,4,5,6-tetramethoxyacetophenone

1-(2,3,4,5,6-pentamethoxyphenyl)ethan-1-one

2,3,4,5,6-pentamethoxybenzoic acid

Downstream raw materials:

C₂₇H₂₈O₉

3′-methoxy-4′-hydroxy-5,6,7,8-tetramethoxyflavone

4'-benzyloxy-3',5,6,7,8-pentamethoxyflavone