Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester
• CAS No.: 104579-21-7
• Molecular Formula: C₄₄H₄₂Cl₂N₃O₁₀P
• Molecular Weight: 874.711
• Mol file: 104579-21-7.mol

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester

There total 1 articles about Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-Hydroxyethyl)pyridine (103-74-2) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + 2,6-dichlorophenyl phosphorodichloridate (53676-19-0) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester (104579-21-7)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1246/cl.1986.699

Reference yield:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester (104579-21-7) → C38H39N3O10P(1-)

Guidance literature:

With triethylamine; 4-nitrobenzaldehyde oxime; In 1,4-dioxane; water; for 4h; Yield given; Ambient temperature;

DOI:10.1246/cl.1986.699

Reference yield:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2,6-dichloro-phenyl ester 2-pyridin-2-yl-ethyl ester (104579-21-7) → (MeO)2Trd(TT-Bz) (80681-88-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-nitrobenzaldoximate, Et₃N / dioxane; H₂O / 4 h / Ambient temperature

2: 75 percent / 8-quinolinesulfonyl chloride, N-methylimidazole / pyridine / 3 h

3: CH₃I / acetonitrile / 18 h / Ambient temperature

With 1-methyl-1H-imidazole; quinoline-8-sulfonyl chloride; triethylamine; methyl iodide; 4-nitrobenzaldehyde oxime; In 1,4-dioxane; pyridine; water; acetonitrile;

DOI:10.1246/cl.1986.699

upstream raw materials:

2-(2-Hydroxyethyl)pyridine

5'-O-(4-4'-dimethoxytrityl)thymidine

2,6-dichlorophenyl phosphorodichloridate

Downstream raw materials:

(MeO)2Trd(TT-Bz)

C₅₅H₅₆N₅O₁₅P

DMTrOTpT