3-CHLORO-4-PHENOXYANILINE

Base Information

• Chemical Name: 3-CHLORO-4-PHENOXYANILINE
• CAS No.: 5335-29-5
• Molecular Formula: C12H10 Cl N O
• Molecular Weight: 219.671
• Hs Code.: 2922299090
• Mol file: 5335-29-5.mol

Synonyms:Aniline,3-chloro-4-phenoxy- (7CI); 2-Chloro-4-aminodiphenyl ether;3-Chloro-4-phenoxyaniline; 4-Amino-2-chlorophenyl phenyl ether; NSC 2914

Chemical Property of 3-CHLORO-4-PHENOXYANILINE

Chemical Property:

• Vapor Pressure: 0.000116mmHg at 25°C
• Boiling Point: 335.9°Cat760mmHg
• Flash Point: 156.9°C
• PSA: 35.25000
• Density: 1.26g/cm³
• LogP: 4.29570

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-phenoxyaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-4-PHENOXYANILINE

There total 6 articles about 3-CHLORO-4-PHENOXYANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-4-nitro-1-phenoxy-benzene (56966-69-9) → 3-chloro-4-phenoxyaniline (5335-29-5)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 110 ℃; for 6h;

DOI:10.1016/j.bmcl.2020.127408

Reference yield: 88.0%

→ 3-chloro-4-phenoxyaniline (5335-29-5)

Guidance literature:

Reference yield:

3-chloro-4-fluoronitrobenzene (350-30-1) + iron (7439-89-6) + phenol (108-95-2,27073-41-2) → 3-chloro-4-phenoxyaniline (5335-29-5)

Guidance literature:

With sodium chloride; sodium hydrogencarbonate; In methanol; acetic acid; dimethyl sulfoxide;

upstream raw materials:

2-chloro-4-nitro-1-phenoxy-benzene

3-chloro-4-fluoronitrobenzene

iron

phenol

Downstream raw materials:

3,5-dichloro-N-(3-chloro-4-phenoxyphenyl)-2-hydroxybenzamide

2-chloro-4-isothiocyanato-1-phenoxybenzene

1-(3-Chloro-4-phenoxyphenyl)thiourea

N³-(3-chloro-4-phenoxyphenyl)-1H-[1,2,4]triazole-3,5-diamine

Refernces

• 1、 Fujii, Shinya,Ishigami-Yuasa, Mari,Isobe, Kiyoshi,Kagechika, Hiroyuki,Kikuchi, Eriko,Mori, Takayasu,Suzuyama, Honoka,Uchida, Shinichi,Watanabe, Yuko. "Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling". supporting information. . Retrieved 2020/07/21.
• 2、 -. "Indole compound as well as preparation method, pharmaceutical composition and application thereof". Paragraph 1168; 1174-1176; 1301; 1307-1309. . Retrieved 2019/12/02.