Technology Process of bromo(chloromethyl)bis(4-fluorophenyl)germane
There total 1 articles about bromo(chloromethyl)bis(4-fluorophenyl)germane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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In
diethyl ether; Petroleum ether;
byproducts: chloro(chloromethyl)bis(4-fluorophenyl)germane, dibrome(chloromethyl)(4-fluorophenyl)germane, MgBr0.5Cl1.5; dropwise addn. of FC6H4MgBr (prepd. from FC6H4Br (190 mmol) and Mg-turnings (190 mmol) in (C2H5)2O) to a stirred soln. of GeCl3(CH2Cl) (87.6 mmol) in (C2H5)2O/petroleum ether at room temp. during 1 h; stirring for 15 h at room temp., refluxing (6 h);; filtering off ppt., washing; removing solvent (reduced pressure); addn. of petroleum ether, cooling (1 d, -20°C); filtering off ppt., washing; removing solvent (reduce pressure); repeated fractional distn. in vac. (Vigreux column); elem. anal.;;
DOI:10.1016/0022-328X(92)88005-4
- Guidance literature:
-
In
diethyl ether;
byproducts: LiBr; dropwise addn. of 1.78 M-soln. of CH3Li (63.2 mmol) in diethyl ether to a stirred soln. of (FC6H4)2Ge(Br)(CH2Cl) (51 mmol) in diethyl ether at room temp. during 30 min; stirring for 15 min at room temp; refluxing for 4.5 h; cooling to 0°C;; treating with satd. aq. NaCl-soln.; sepg. org. phase, extg. aq. layer with diethyl ether (3 times); drying combined org. layers over anhydrous Na2SO4; removing solvent under reduced pressure; distg.residue in vac. (Vigreux column); elem. anal.;;
DOI:10.1016/0022-328X(92)88005-4
