(chloromethyl)bis(4-fluorophenyl)methylgermane

Base Information

Chemical Name:(chloromethyl)bis(4-fluorophenyl)methylgermane
CAS No.:145066-07-5
Molecular Formula:C₁₄H₁₃ClF₂Ge
Molecular Weight:327.297
Hs Code.:

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Chemical Property of (chloromethyl)bis(4-fluorophenyl)methylgermane

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Technology Process of (chloromethyl)bis(4-fluorophenyl)methylgermane

There total 1 articles about (chloromethyl)bis(4-fluorophenyl)methylgermane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145066-06-4
bromo(chloromethyl)bis(4-fluorophenyl)germane

: 917-54-4
methyllithium

: 145066-07-5
(chloromethyl)bis(4-fluorophenyl)methylgermane

Guidance literature:: In diethyl ether; byproducts: LiBr; dropwise addn. of 1.78 M-soln. of CH3Li (63.2 mmol) in diethyl ether to a stirred soln. of (FC6H4)2Ge(Br)(CH2Cl) (51 mmol) in diethyl ether at room temp. during 30 min; stirring for 15 min at room temp; refluxing for 4.5 h; cooling to 0°C;; treating with satd. aq. NaCl-soln.; sepg. org. phase, extg. aq. layer with diethyl ether (3 times); drying combined org. layers over anhydrous Na2SO4; removing solvent under reduced pressure; distg.residue in vac. (Vigreux column); elem. anal.;;
DOI:10.1016/0022-328X(92)88005-4

Reference yield: 95.0%

: 145066-07-5
(chloromethyl)bis(4-fluorophenyl)methylgermane

: 7681-82-5,24359-64-6,41927-88-2,115813-40-6
sodium iodide

: 145066-08-6
bis(4-fluorophenyl)(iodomethyl)methylgermane

Guidance literature:: In acetone; byproducts: NaCl; stirring mixt. of (FC6H4)2Ge(CH3)(CH2Cl) (39.4 mmol) and NaI (118 mmol) in acetone for 21 h under reflux; cooling to room temp.;; pptn.; filtering off, washing with petroleum ether; removing solvent (reduced pressure); addn. of petroleum ether, keeping mixt. for 1 h at room temp.; filtering off ppt., removing solvent (reduced pressure); vac. distn. (Vigreux column); elem. anal.;;
DOI:10.1016/0022-328X(92)88005-4