1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

Base Information

Chemical Name:1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide
CAS No.:180600-09-3
Molecular Formula:C₃₅H₄₃N₂O₄P
Molecular Weight:586.711
Hs Code.:

1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

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Chemical Property of 1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

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Technology Process of 1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

There total 4 articles about 1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153223-10-0
(2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol

: 180600-09-3
1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / camphor sulfonic acid / CH₂Cl₂ / 48 h / Ambient temperature

2: 100 percent / hydrogen / 10percent Pd/C / tetrahydrofuran; ethanol / 18 h / 760 Torr

3: 64 percent / triethylamine / tetrahydrofuran / 16 h / Ambient temperature

4: sodium hydride / dimethylformamide

With camphor-10-sulfonic acid; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7524

Reference yield:

: 177574-46-8
dibenzyl ((1R,1'R)-((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate

: 180600-09-3
1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / hydrogen / 10percent Pd/C / tetrahydrofuran; ethanol / 18 h / 760 Torr

2: 64 percent / triethylamine / tetrahydrofuran / 16 h / Ambient temperature

3: sodium hydride / dimethylformamide

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7524

Reference yield:

: 770-12-7
O-phenyl phosphorodichloridate

: 180600-09-3
1,3-bis(cyclopropylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / triethylamine / tetrahydrofuran / 16 h / Ambient temperature

2: sodium hydride / dimethylformamide

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7524