2-Amino-3-methoxybenzamide

Base Information

• Chemical Name: 2-Amino-3-methoxybenzamide
• CAS No.: 106782-78-9
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID10594900
• Nikkaji Number: J3.002.684E
• Wikidata: Q82489822
• Mol file: 106782-78-9.mol

Synonyms:2-Amino-3-methoxybenzamide;106782-78-9;3-METHOXY-2-AMINOBENZAMIDE;Benzamide, 2-amino-3-methoxy-;2-Amino-3-methoxy-benzamide;3-methoxyanthranilamide;SCHEMBL165834;DTXSID10594900;KTSGITANKLIJRS-UHFFFAOYSA-N;MFCD09753573;AKOS006327343;BS-26079;DB-111876;CS-0205683;F15887;Z1198223462

Chemical Property of 2-Amino-3-methoxybenzamide

Chemical Property:

• Melting Point: 162-164°C
• Boiling Point: 280.7±25.0 °C(Predicted)
• PKA: 15.58±0.50(Predicted)
• PSA: 79.33000
• Density: 1.236±0.06 g/cm3(Predicted)
• LogP: 1.84170
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO, Methanol
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-2-aminobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1N)C(=O)N
• Uses: 3-Methoxy-2-aminobenzamide (cas# 106782-78-9) is a compound useful in organic synthesis.

Technology Process of 2-Amino-3-methoxybenzamide

There total 9 articles about 2-Amino-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-amino-3-methoxybenzoic acid (3177-80-8) → 3-methoxy-2-aminobenzamide (106782-78-9)

Guidance literature:

2-amino-3-methoxybenzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 70 ℃; for 1h; Inert atmosphere;

With ammonium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1039/c1ob05430a

Reference yield:

3-methoxy-2-nitro-benzamide (99595-85-4) → 3-methoxy-2-aminobenzamide (106782-78-9)

Guidance literature:

aluminum nickel; In ethanol;

Reference yield:

3-methoxyisatoic anhydride (34954-65-9) → 3-methoxy-2-aminobenzamide (106782-78-9)

Guidance literature:

With ammonium carbonate; In 1,4-dioxane; at 60 ℃;

DOI:10.1021/acs.jafc.5b01762

upstream raw materials:

3-methoxy-2-nitro-benzamide

2-amino-3-methoxybenzoic acid

C₈H₈ClNO₂

3-methoxyisatoic anhydride

Downstream raw materials:

3-methoxy-2-(4-nitrobenzamido)benzamide

2-N-Acetylamino-3-methoxybenzamide

8-Methoxy-2-(4'-cyanophenyl)quinazolin-4-[3 H]-one

NU 1065