4(1H)-Quinazolinone, 8-methoxy-2-methyl- (9CI)

Base Information

• Chemical Name: 4(1H)-Quinazolinone, 8-methoxy-2-methyl- (9CI)
• CAS No.: 90915-45-0
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.19900
• Hs Code.: 29334900
• Mol file: 90915-45-0.mol

Synonyms:8-Methoxy-2-methyl-3H-chinazolin-4-on;8-methoxy-2-methyl-3H-quinazolin-4-one;8-METHOXY-2-METHYL-4(3H)-QUINAZOLINONE;8-methoxy-2-methyl-4-oxo-3,4-dihydroquinazoline;8-Methoxy-2-methylquinazolin-4-[3 H]-one;

Chemical Property of 4(1H)-Quinazolinone, 8-methoxy-2-methyl- (9CI)

Chemical Property:

• PSA: 54.98000
• LogP: 1.24010

Purity/Quality:

97% ^*data from raw suppliers

8-Methoxy-2-methyl-4(3H)-quinazolinone ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Methoxy-2-methyl-4(3H)-quinazolinone (cas# 90915-45-0) is a compound useful in organic synthesis.

Technology Process of 4(1H)-Quinazolinone, 8-methoxy-2-methyl- (9CI)

There total 12 articles about 4(1H)-Quinazolinone, 8-methoxy-2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-methoxy-2-aminobenzamide (106782-78-9) + acetyl chloride (75-36-5) → 8-methoxy-2-methyl-4-oxo-3,4-dihydroquinazoline (90915-45-0)

Guidance literature:

With pyridine; In tetrahydrofuran; at 25 ℃;

DOI:10.1021/jm980273t

Reference yield: 81.0%

8-Methoxy-2-methyl-2,3-dihydroquinazolin-4(1H)-one → 8-methoxy-2-methyl-4-oxo-3,4-dihydroquinazoline (90915-45-0)

Guidance literature:

With palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2016.08.018

Reference yield: 67.0%

2-N-Acetylamino-3-methoxybenzamide (172462-98-5) → 8-methoxy-2-methyl-4-oxo-3,4-dihydroquinazoline (90915-45-0)

Guidance literature:

With sodium hydroxide; Ambient temperature;

DOI:10.1021/jm980273t

upstream raw materials:

8-methoxy-2-methyl-4H-benzo[d][1,3]oxazin-4-one

2-methoxyacetanilide

urethane

2-amino-3-methoxybenzoic acid

Downstream raw materials:

2-(3,4-diethoxy-trans-styryl)-8-methoxy-3H-quinazolin-4-one

8-methoxy-2-trans-quinazolin-4-one

8-methoxy-2-(4-methoxy-trans-styryl)-3H-quinazolin-4-one

8-hydroxy-2-methyl-4(3H)-quinazolinone