Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide

Base Information

• Chemical Name: Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide
• CAS No.: 106787-27-3
• Molecular Formula: C19H18NO3P.BrH
• Molecular Weight: 420.243
• Mol file: 106787-27-3.mol

Synonyms:

Chemical Property of Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide

There total 9 articles about Phosphonic acid, (aminophenylmethyl)-, diphenyl ester, hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

Diphenyl α-(diethoxythiophosphinylamino)-benzylphosphonate (110814-36-3) → diphenyl α-aminobenzylphosphonate hydrobromide (106787-27-3)

Guidance literature:

With hydrogen bromide; In acetic acid; for 0.5h; Ambient temperature;

DOI:10.1055/s-1986-31790

Reference yield:

triphenyl phosphite (101-02-0) → diphenyl α-aminobenzylphosphonate hydrobromide (106787-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr / acetic acid; H₂O

With hydrogen bromide; In water; acetic acid;

DOI:10.1016/j.tetlet.2006.04.058

Reference yield:

benzaldehyde (100-52-7) → diphenyl α-aminobenzylphosphonate hydrobromide (106787-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / SOCl₂, AcOH / 1) room temperature, 20 min, 2) reflux, 3 h

2: 97 percent / HBr(32.6percent), AcOH / Ambient temperature

With thionyl chloride; hydrogen bromide; acetic acid;

DOI:10.1055/s-1990-26927

upstream raw materials:

Diphenyl α-(diethoxythiophosphinylamino)-benzylphosphonate

triphenyl phosphite

benzaldehyde

diphenyl hydrogen phosphite

Downstream raw materials:

(isocyanato-phenyl-methyl)-phosphonic acid diphenyl ester

diphenyl (isothiocyanato(phenyl)methyl)phosphonate

diphenyl [1-(1-amino)benzyl]phosphonate

(formylamino-phenyl-methyl)-phosphonic acid diphenyl ester

Refernces

• 1、 Psurski, Mateusz,Pigula, Marta,Winiarski, Lukasz,Oleksyszyn, Jozef,Ciekot, Jaroslaw,Wietrzyk, Joanna. "Convenient syntheses of novel 1-isothiocyano-alkylphosphonate diphenyl ester derivatives with potential biological activity". . p. 5845 - 5847,3. Retrieved 2020/08/20.
• 2、 Huang, Junmin,Chen, Ruyu. "Synthesis and bioactivities of 1,3,2-benzodiazaphosphorin-2-carboxamide 2-oxides containing α-aminophosphonate groups". . p. 97 - 101. Retrieved 2007/10/03.