Diphenoxyphosphoryl(phenyl)methanamine

Base Information

• Chemical Name: Diphenoxyphosphoryl(phenyl)methanamine
• CAS No.: 84044-04-2
• Molecular Formula: C19H18NO3P
• Molecular Weight: 339.331
• DSSTox Substance ID: DTXSID90465609
• Nikkaji Number: J323.253K
• Mol file: 84044-04-2.mol

Synonyms:84044-04-2;AGN-PC-008WJ5;SCHEMBL5147638;DTXSID90465609

Chemical Property of Diphenoxyphosphoryl(phenyl)methanamine

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 339.10243043
• Heavy Atom Count: 24
• Complexity: 389

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(N)P(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3

Technology Process of Diphenoxyphosphoryl(phenyl)methanamine

There total 7 articles about Diphenoxyphosphoryl(phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenyl α-aminobenzylphosphonate hydrobromide (106787-27-3) → diphenyl [1-(1-amino)benzyl]phosphonate (84044-04-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1002/hc.20396

Reference yield:

C19H18NO3P*C7H8O3S → diphenyl [1-(1-amino)benzyl]phosphonate (84044-04-2)

Guidance literature:

With ammonium hydroxide; In water; at 20 ℃; for 0.333333h;

DOI:10.1002/anie.201308514

Reference yield:

benzaldehyde (100-52-7) → diphenyl [1-(1-amino)benzyl]phosphonate (84044-04-2)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium hydroxide / water / 48 h / 20 °C

2: chloroform / Reflux

3: tetrahydrofuran / 4 h / 0 °C

4: ammonium hydroxide / water / 0.33 h / 20 °C

With ammonium hydroxide; In tetrahydrofuran; chloroform; water;

DOI:10.1002/anie.201308514

upstream raw materials:

O,O-diphenyl {[(benzyloxy)carbonyl]amino}(phenyl)methylphosphonate

diphenyl α-aminobenzylphosphonate hydrobromide

benzaldehyde

hydrobenzamide

Downstream raw materials:

C₂₃H₂₂NO₆P

diphenyl ((4R,5R)-4,5-diphenyl-2-thioxooxazolidin-4-yl)phosphonate

diphenyl ((4R,5R)-4-phenyl-2-thioxo-5-(m-tolyl)-1-tosylimidazolidin-4-yl)phosphonate

diphenyl ((4R,5R)-4-phenyl-2-thioxo-5-(o-tolyl)-1-tosylimidazolidin-4-yl)phosphonate