5-(3,5-Dichlorophenyl)furan-2-carbaldehyde

Base Information

• Chemical Name: 5-(3,5-Dichlorophenyl)furan-2-carbaldehyde
• CAS No.: 106827-27-4
• Molecular Formula: C11H6Cl2O2
• Molecular Weight: 241.073
• DSSTox Substance ID: DTXSID301255897
• Mol file: 106827-27-4.mol

Synonyms:5-(3,5-dichlorophenyl)furan-2-carbaldehyde;106827-27-4;Cambridge id 6250037;SCHEMBL5468753;DTXSID301255897;5-(3,5-Dichlorophenyl)furaldehyde;BBL024117;MFCD02615001;STL290866;AKOS000108206;5-(3,5-Dichlorophenyl)-2-furaldehyde;VS-07678;BB 0245472;CS-0366902;5-(3,5-Dichlorophenyl)-2-furancarboxaldehyde;5-(3,5-Dichloro-phenyl)-furan-2-carbaldehyd e

Chemical Property of 5-(3,5-Dichlorophenyl)furan-2-carbaldehyde

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 239.9744848
• Heavy Atom Count: 15
• Complexity: 225

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(OC(=C1)C2=CC(=CC(=C2)Cl)Cl)C=O

Technology Process of 5-(3,5-Dichlorophenyl)furan-2-carbaldehyde

There total 3 articles about 5-(3,5-Dichlorophenyl)furan-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-formylfurane-2-boronic acid (27329-70-0) + 3,5-dichloroiodobenzene (3032-81-3) → 5-(3,5-dichlorophenyl)furan-2-carbaldehyde (106827-27-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 65 ℃; for 1h;

DOI:10.1016/j.ejmech.2016.12.024

Reference yield: 76.0%

5-bromo-2-furancarboxaldehyde (1899-24-7) + (3,5-dichlorophenyl)boronic acid (67492-50-6) → 5-(3,5-dichlorophenyl)furan-2-carbaldehyde (106827-27-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; at 70 ℃; Inert atmosphere; Sealed tube;

DOI:10.1016/j.ejmech.2019.111857

Reference yield: 32.0%

furfural (98-01-1) + 3,5-Dichloroaniline (626-43-7) → 5-(3,5-dichlorophenyl)furan-2-carbaldehyde (106827-27-4)

Guidance literature:

3,5-Dichloroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 110 ℃; for 0.333333h;

furfural; In water; acetone; at 0 ℃; for 0.25h;

With copper dichloride; In water; acetone; at 0 - 20 ℃; for 14h;

DOI:10.1016/j.bmc.2012.08.062

upstream raw materials:

furfural

3,5-Dichloroaniline

5-formylfurane-2-boronic acid

3,5-dichloroiodobenzene

Downstream raw materials:

N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(3,5-dichlorophenyl)-2-furamide

N-{3-[4-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-(3,5-dichlorophenyl)-2-furamide

5-(3,5-dichlorophenyl)-N-{2,4-dioxo-3-[(pyridin-4-yl)methyl]imidazolidin-1-yl}-2-furamide

1-{[5-(3,5-dichlorophenyl)furfurylidene]amino}imidazolidine-2,4-dione