Technology Process of 5-(3,5-dichlorophenyl)-N-{2,4-dioxo-3-[(pyridin-4-yl)methyl]imidazolidin-1-yl}-2-furamide
There total 5 articles about 5-(3,5-dichlorophenyl)-N-{2,4-dioxo-3-[(pyridin-4-yl)methyl]imidazolidin-1-yl}-2-furamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(3,5-dichlorophenyl)-N-(2,4-dioxoimidazolidin-1-yl)-2-furamide;
With
sodium carbonate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 0.166667h;
Inert atmosphere;
4-(bromomethyl)pyridine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.062
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 - 110 °C
1.2: 0.25 h / 0 °C
1.3: 14 h / 0 - 20 °C
2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C
3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C
4.1: sodium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C / Inert atmosphere
4.2: 4 h / 0 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium nitrite;
In
methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
1.1: |Meerwein Arylation / 1.2: |Meerwein Arylation / 1.3: |Meerwein Arylation;
DOI:10.1016/j.bmc.2012.08.062
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C
2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C
3.1: sodium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C / Inert atmosphere
3.2: 4 h / 0 - 20 °C / Inert atmosphere
With
4-methyl-morpholine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.08.062
