3032-81-3

Basic information

• Product Name: 3,5-Dichloroiodobenzene
• Synonyms: 1,3-DICHLORO-5-IODOBENZENE;3,5-DICHLOROIODOBENZENE;1,3-dichloro-5-iodo-benzen;Benzene, 1,3-dichloro-5-iodo-;3,5-Dichloro-1-iodobenzene;3,5-Dichlorophenyl iodide;1,3-Dichloro-5-iodobenzene,99%;1,3-Dichloro-5-iodobenzene, 99% 5GR
• CAS NO: 3032-81-3
• Molecular Formula: C₆H₃Cl₂I
• Molecular Weight: 272.9
• EINECS: 221-216-3
• Product Categories: Chlorine Compounds;Iodine Compounds;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 3032-81-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 56-58 °C(lit.)
• Boiling Point: 127°C 20mm
• Flash Point: 127°C/20mm
• Appearance: Pale yellow to pale orange crystals or powder
• Density: 1.9882 (estimate)
• Vapor Pressure: 0.0222mmHg at 25°C
• Refractive Index: 1.642
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive: Light Sensitive
• BRN: 2242455
• CAS DataBase Reference: 3,5-Dichloroiodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloroiodobenzene(3032-81-3)
• EPA Substance Registry System: 3,5-Dichloroiodobenzene(3032-81-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 3032-81-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow to pale orange crystals or powder

Uses

Different sources of media describe the Uses of 3032-81-3 differently. You can refer to the following data:
1. 3,5-Dichloroiodobenzene is used as a glycolate oxidase inhibitors.
2. 3,5-Dichloroiodobenzene was used as selective reagent for the derivatization of proximinal bifunctional compounds.

InChI:InChI=1/C6H3Cl2I/c7-4-1-5(8)3-6(9)2-4/h1-3H

Upstream product

• 51-36-5 3,5-dichlorobenzoic acid 
• 68716-51-8 2-(3,5-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 541-73-1 1,3-Dichlorobenzene 
• 19752-55-7 1-bromo-3,5-dichlorobenzene 
• 108-70-3 1,3,5-trichlorobenzene 
• 554-00-7 2,4-Dichloroaniline 
• 618-62-2 3,5-dichloro-1-nitrobenzene 
• 626-43-7 3,5-Dichloroaniline 
• 697-90-5 2,4-dichloro-6-iodoaniline 

Downstream Products

• 56558-18-0 2,3',4,5',6-pentachlorobiphenyl 
• 68194-12-7 2,3',4,5,5'-pentachlorobiphenyl 
• 70362-41-3 2,3,3',4,5'-pentachlorobiphenyl 
• 74472-46-1 2,3,3',5,5',6-hexachlorobiphenyl 
• 74472-51-8 2,3,3',4,5,5',6-heptachlorobiphenyl 
• 177167-52-1 1,3-dichloro-5-iodo-2-methylbenzene 
• 1271807-65-8 trans ((R)-4-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-(trifluoromethyl)piperidin-3-ylamino)-3-(3,5-dichlorophenylamino)-4-oxobutyl)dimethylsulfonium 
• 1271810-76-4 (R)-(3-carboxy-3-(3-chloro-5-fluorophenylamino)propyl)dimethylsulfonium iodide 
• 1437779-31-1 5-(5-(3,5-dichloro-4-methylphenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol 
• 942069-73-0 2-(3,5-dichloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1432445-09-4 1,3-dichloro-2-methyl-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1451093-06-3 1-(4-bromo-phenylsulfanyl)-3,5-dichloro-benzene 
• 90-04-0 2-methoxy-phenylamine 
• 613-55-8 2,2'-dimethoxyazobenzene 

Relevant articles and documents

Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange

We report an efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic analysis suggest a unique mechanism involving C?P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution.

Sterically controlled iodination of arenes via iridium-catalyzed C-H borylation

A mild method to prepare aryl and heteroaryl iodides by sequential C-H borylation and iodination is reported. The regioselectivity of this process is controlled by steric effects on the C-H borylation step and is complementary to existing methods to form aryl iodides. The iodination of boronic esters has potential for the synthesis of radiolabeled aryl iodides, as demonstrated by the concise synthesis of a potential tracer for SPECT imaging.

Cobalt-catalyzed preparation of arylindium reagents from aryl and heteroaryl bromides

A cobalt-bathophenanthroline catalyst has been developed for the direct preparation of a variety of arylindium reagents from the corresponding aryl and heteroaryl bromides in the presence of indium metal and lithium chloride. The thus-formed arylindium reagents undergo efficient palladium-catalyzed cross-coupling reactions with aryl iodides, tolerating various functional groups including hydroxy and free amino groups.