C₂₇H₂₈N₂O₃

Base Information

Chemical Name:C₂₇H₂₈N₂O₃
CAS No.:1300691-47-7
Molecular Formula:C₂₇H₂₈N₂O₃
Molecular Weight:428.531
Hs Code.:

C<sub>27</sub>H<sub>28</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₇H₂₈N₂O₃

Chemical Property:

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Technology Process of C₂₇H₂₈N₂O₃

There total 8 articles about C₂₇H₂₈N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300031-74-6
methyl 4-((2S,4R)-1-acetyl-4-amino-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

: 5720-05-8
4-methylphenylboronic acid

: 1300691-47-7
C₂₇H₂₈N₂O₃

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm5010539

Reference yield:

: 106-40-1
4-bromo-aniline

: 1300691-47-7
C₂₇H₂₈N₂O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 12 h / 20 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 2 h / 0 °C

4.1: triethylamine; copper diacetate / dichloromethane / 20 °C

5.1: hydrogenchloride / methanol; water / 3 h / Reflux

6.1: L-Lactic acid / ethanol; water / 0.5 h / Reflux

6.2: 0.5 h

6.3: 0.33 h / Reflux; Resolution of racemate

7.1: triethylamine; copper diacetate / dichloromethane / 20 °C

With pyridine; hydrogenchloride; L-Lactic acid; boron trifluoride diethyl etherate; copper diacetate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; 4.1: |Chan-Lam Coupling / 7.1: |Chan-Lam Coupling;
DOI:10.1021/jm5010539

Reference yield:

: methyl 4-[1-acetyl-4-(formylamino)-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl]benzoate

: 1300691-47-7
C₂₇H₂₈N₂O₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / methanol; water / 3 h / Reflux

2.1: L-Lactic acid / ethanol; water / 0.5 h / Reflux

2.2: 0.5 h

2.3: 0.33 h / Reflux; Resolution of racemate

3.1: triethylamine; copper diacetate / dichloromethane / 20 °C

With hydrogenchloride; L-Lactic acid; copper diacetate; triethylamine; In methanol; ethanol; dichloromethane; water; 3.1: |Chan-Lam Coupling;
DOI:10.1021/jm5010539