methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate

Base Information

• Chemical Name: methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate
• CAS No.: 133657-29-1
• Molecular Formula: C₂₃H₂₈N₄O₆
• Molecular Weight: 456.499
• Mol file: 133657-29-1.mol

Synonyms:

Chemical Property of methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate

There total 3 articles about methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-1,3-dipropyluracil (41862-14-0) → methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate (133657-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77.9 percent / ethanol / Heating

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) RT, 20 h

With sodium hydride; In ethanol;

DOI:10.3987/COM-90-5554

Reference yield:

methyl 2-(3-nitrophenylmethylene)acetoacetate (39562-17-9) → methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate (133657-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77.9 percent / ethanol / Heating

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) RT, 20 h

With sodium hydride; In ethanol;

DOI:10.3987/COM-90-5554

Reference yield:

7-Methyl-5-(3-nitro-phenyl)-2,4-dioxo-1,3-dipropyl-1,2,3,4,5,8-hexahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester (133657-13-3) + methyl iodide (74-88-4) → methyl 1,2,3,4,5,8-hexahydro-7,8-dimethyl-5-(3-nitrophenyl)-1,3-dipropyl-2,4-dioxopyrido<2,3-d>pyrimidine-6-carboxylate (133657-29-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, RT, 30 min, 2.) RT, 20 h;

DOI:10.3987/COM-90-5554

upstream raw materials:

7-Methyl-5-(3-nitro-phenyl)-2,4-dioxo-1,3-dipropyl-1,2,3,4,5,8-hexahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester

methyl iodide

6-amino-1,3-dipropyluracil

methyl 2-(3-nitrophenylmethylene)acetoacetate