41862-14-0

Basic information

• Product Name: 6-AMINO-1,3-DIPROPYLURACIL
• Synonyms: 1,3-DIPROPYL-6-AMINOURACIL;AKOS BBS-00006550;6-AMINO-1,3-DIPROPYL-1H-PYRIMIDINE-2,4-DIONE;6-AMINO-1,3-DIPROPYL-2,4(1H,3H)-PYRIMIDINEDIONE;6-AMINO-1,3-DIPROPYLURACIL;SALOR-INT L157864-1EA;SPECS AB-323/25048034
• CAS NO: 41862-14-0
• Molecular Formula: C₁₀H₁₇N₃O₂
• Molecular Weight: 211.26
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates;Nucleotides;Building Blocks;C9 to C11;Chemical Synthesis;Heterocyclic Building Blocks;Pyrimidines
• Mol File: 41862-14-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 134-139 °C
• Boiling Point: 308.3 °C at 760 mmHg
• Flash Point: 140.3 °C
• Appearance: White crystalline solid
• Density: 1.12 g/cm³
• Vapor Pressure: 0.000685mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: -20°C Freezer
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: 5.17±0.70(Predicted)
• CAS DataBase Reference: 6-AMINO-1,3-DIPROPYLURACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-1,3-DIPROPYLURACIL(41862-14-0)
• EPA Substance Registry System: 6-AMINO-1,3-DIPROPYLURACIL(41862-14-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 41862-14-0(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

Different sources of media describe the Uses of 41862-14-0 differently. You can refer to the following data:
1. As an intermediate, 6-AMino-1,3-dipropyluracil can been used for the sythesis of xanthine derivatives
2. 6-Amino-1,3-dipropyluracil can be used in the synthesis of compounds of medicinal interest such as deazaflavins, pyrido[2,3-d]pyrimidines and tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline tetraones.

InChI:InChI=1/C10H17N3O2/c1-3-5-12-8(11)7-9(14)13(6-4-2)10(12)15/h7H,3-6,11H2,1-2H3

Upstream product

• 623-95-0 1,3-dipropylurea 
• 372-09-8 cyanoacetic acid 
• 859732-95-9 2-cyano-N-propyl-N-(propylcarbamoyl)acetamide 
• 38014-56-1 N-Aethyl-N'-n-propyl-harnstoff 

Downstream Products

• 102146-07-6 8-Cyclopentyl-1,3-dipropylxanthine 
• 127252-57-7 6-Amino-5-{[1-phenyl-meth-(E)-ylidene]-amino}-1,3-dipropyl-1H-pyrimidine-2,4-dione 
• 132940-68-2 N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-phenyl-propionamide 
• 127252-60-2 6-Amino-5-{[1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dipropyl-1H-pyrimidine-2,4-dione 
• 132940-49-9 4-{[(E)-6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylimino]-methyl}-benzonitrile 
• 132940-71-7 (E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-phenyl-acrylamide 
• 132940-39-7 8-Phenethyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione 
• 85872-53-3 1,3-dipropyl-8-phenylxanthine 
• 132940-42-2 (E)-1,3-dipropyl-8-styrylxanthine 
• 94781-76-7 8-(4-hydroxyphenyl)-1,3-dipropyl-1,3,7-trihydropurine-2,6-dione 
• 116545-90-5 1,3-dipropyl-8-(4-cyanophenyl)xanthine 
• 340021-17-2 3-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl)propanoic acid 

Relevant articles and documents

Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1Receptor in Living Cells

The adenosine A1 receptor (A1AR) is a G-protein-coupled receptor (GPCR) that provides important therapeutic opportunities for a number of conditions including congestive heart failure, tachycardia, and neuropathic pain. The development of A1AR-selective fluorescent ligands will enhance our understanding of the subcellular mechanisms underlying A1AR pharmacology facilitating the development of more efficacious and selective therapies. Herein, we report the design, synthesis, and application of a novel series of A1AR-selective fluorescent probes based on 8-functionalized bicyclo[2.2.2]octylxanthine and 3-functionalized 8-(adamant-1-yl) xanthine scaffolds. These fluorescent conjugates allowed quantification of kinetic and equilibrium ligand binding parameters using NanoBRET and visualization of specific receptor distribution patterns in living cells by confocal imaging and total internal reflection fluorescence (TIRF) microscopy. As such, the novel A1AR-selective fluorescent antagonists described herein can be applied in conjunction with a series of fluorescence-based techniques to foster understanding of A1AR molecular pharmacology and signaling in living cells.

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.

Immunosuppressive effects of 8-substituted xanthine derivatives

The invention relates to a novel use of 8-substituted xanthine derivatives for the manufacture of a medicament for the treatment of auto-immuno disorders.