[5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester
CAS No.:206133-42-8
Molecular Formula:C₄₂H₄₈N₄O₇
Molecular Weight:720.866
Hs Code.:

[5-[2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid <i>tert</i>-butyl ester

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Suppliers and Price of [5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of [5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

There total 7 articles about [5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₉N₃O₄

: 35661-40-6
N-Fmoc L-Phe

: 206133-42-8
[5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: N-Fmoc L-Phe; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 16h; Inert atmosphere;

C₁₈H₂₉N₃O₄; With triethylamine; In dichloromethane; for 4h; Inert atmosphere;
DOI:10.1039/c4cc09829c

Reference yield:

: 2418-95-3
(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

: 206133-42-8
[5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHCO₃ / 1,2-dimethoxy-ethane

2: di-tert-butyl dicarbonate; pyridine / dimethylformamide

With pyridine; di-tert-butyl dicarbonate; sodium hydrogencarbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.05.089

Reference yield:

: 101214-43-1
Fmoc-Phe-ONSu

: 206133-42-8
[5-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-5-(4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHCO₃ / 1,2-dimethoxy-ethane

2: di-tert-butyl dicarbonate; pyridine / dimethylformamide

With pyridine; di-tert-butyl dicarbonate; sodium hydrogencarbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.05.089