2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester

Base Information

Chemical Name:2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester
CAS No.:224044-62-6
Molecular Formula:C₂₄H₂₆N₂O₉
Molecular Weight:486.478
Hs Code.:
DSSTox Substance ID:DTXSID001121037
Nikkaji Number:J1.142.776F

Synonyms:224044-62-6;2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester;diethyl 2-acetamido-2-[2-(2-nitro-3-phenylmethoxyphenyl)-2-oxoethyl]propanedioate;2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Este;CGLSCGDZMYKKLH-UHFFFAOYSA-N;DTXSID001121037;2-[beta-Oxo-2-nitro-3-(benzyloxy)phenethyl]-2-(acetylamino)malonic acid diethyl ester;1,3-Diethyl 2-(acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioate

Suppliers and Price of 2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:13
Exact Mass:486.16383041
Heavy Atom Count:35
Complexity:755

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(CC(=O)C1=C(C(=CC=C1)OCC2=CC=CC=C2)[N+](=O)[O-])(C(=O)OCC)NC(=O)C

Technology Process of 2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester

There total 2 articles about 2-(Acetylamino)-2-[2-[2-nitro-3-(phenylmethoxy)phenyl]-2-oxoethyl]propanedioic Acid 1,3-Diethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 224044-61-5
2-bromo-1-(2-nitro-3-phenylmethoxyphenyl)ethanone

: 224044-62-6
diethyl (acetylamino)<2-(2-nitro-3-phenylmethoxyphenyl)-2-oxoethyl>propanedioate

Guidance literature:: With sodium ethanolate; In ethanol; for 2h; Ambient temperature;
DOI:10.1021/jo982321n

Reference yield:

: 224044-60-4
2-nitro-3-benzyloxyacetophenone

: 224044-62-6
diethyl (acetylamino)<2-(2-nitro-3-phenylmethoxyphenyl)-2-oxoethyl>propanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Br₂*dioxane / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 21 percent / EtONa / ethanol / 2 h / Ambient temperature

With sodium ethanolate; dioxane dibromide; In ethanol; dichloromethane;
DOI:10.1021/jo982321n