Technology Process of O-(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-threonine tert-butyl ester
There total 8 articles about O-(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-threonine tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / BF3*OEt2 / cyclohexane; CH2Cl2 / 14 h
2: 92 percent / H2 / Pd(OH)2-C (20 percent Pd) / ethanol; acetic acid / 36 h
3: 98 percent / molecular sieve (3 Angstroem), 1 M t-BuOK / toluene; tetrahydrofuran / 5 h
4: H2 / platinized Raney Ni T4 / ethanol / 12 h / Ambient temperature
5: pyridine / 3 h
With
3 A molecular sieve; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen;
palladium hydroxide - carbon; platinized Raney Ni T4;
In
tetrahydrofuran; pyridine; ethanol; dichloromethane; cyclohexane; acetic acid; toluene;
DOI:10.1002/(SICI)1099-0690(199905)1999:5<1167::AID-EJOC1167>3.0.CO;2-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / BF3*OEt2 / cyclohexane; CH2Cl2 / 14 h
2: 92 percent / H2 / Pd(OH)2-C (20 percent Pd) / ethanol; acetic acid / 36 h
3: 98 percent / molecular sieve (3 Angstroem), 1 M t-BuOK / toluene; tetrahydrofuran / 5 h
4: H2 / platinized Raney Ni T4 / ethanol / 12 h / Ambient temperature
5: pyridine / 3 h
With
3 A molecular sieve; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen;
palladium hydroxide - carbon; platinized Raney Ni T4;
In
tetrahydrofuran; pyridine; ethanol; dichloromethane; cyclohexane; acetic acid; toluene;
DOI:10.1002/(SICI)1099-0690(199905)1999:5<1167::AID-EJOC1167>3.0.CO;2-2
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / molecular sieve (3 Angstroem), 1 M t-BuOK / toluene; tetrahydrofuran / 5 h
2: H2 / platinized Raney Ni T4 / ethanol / 12 h / Ambient temperature
3: pyridine / 3 h
With
3 A molecular sieve; potassium tert-butylate; hydrogen;
platinized Raney Ni T4;
In
tetrahydrofuran; pyridine; ethanol; toluene;
DOI:10.1002/(SICI)1099-0690(199905)1999:5<1167::AID-EJOC1167>3.0.CO;2-2
