(S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate
CAS No.:1253575-96-0
Molecular Formula:C₄₃H₅₂FN₉O₅
Molecular Weight:793.942
Hs Code.:

(S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

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Technology Process of (S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

There total 7 articles about (S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886372-63-0
5-fluoro-6-methoxypyridin-3-ylamine

: 1253575-96-0
(S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0.58 h / Cooling with ice; Inert atmosphere

2: hydrogenchloride; water / tetrahydrofuran; methanol / 0.17 h / 20 °C / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 0.42 h / 0 °C

4: triethylamine / dichloromethane / 2 h

5: 2,2,6,6-tetramethyl-piperidine / acetonitrile / Reflux

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm300846z

Reference yield:

: 1253571-14-0
5-(4-(bis(4-methoxybenzyl)-amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)nicotinaldehyde

: 1253575-96-0
(S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 0.42 h / 0 °C

2: triethylamine / dichloromethane / 2 h

3: 2,2,6,6-tetramethyl-piperidine / acetonitrile / Reflux

With 2,2,6,6-tetramethyl-piperidine; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jm300846z

Reference yield:

: 1253573-75-9
4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253575-96-0
(S)-tert-butyl 4-((S)-1-(5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-ethyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

2: cesium fluoride; Pd^II(OAc)₂(XPhos) / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere

3: sodium tetrahydroborate / tetrahydrofuran / 0.17 h / 0 °C

4: triethylamine / dichloromethane / 2 h

5: 2,2,6,6-tetramethyl-piperidine / acetonitrile / Reflux

With 2,2,6,6-tetramethyl-piperidine; sodium tetrahydroborate; Pd^II(OAc)₂(XPhos); triethylamine; cesium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile; 2: |Stille Cross Coupling;
DOI:10.1021/jm300846z