(6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Base Information

Chemical Name:(6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.:107937-01-9
Molecular Formula:C10H12N2O3S
Molecular Weight:240.283
Hs Code.:
UNII:4ZE15V22RD
DSSTox Substance ID:DTXSID20148332
Wikidata:Q27260710
Mol file:107937-01-9.mol

Synonyms:120709-09-3;(6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;107937-01-9;(6R,7R)-7-Amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Cefprozil impurity F [EP];UNII-4ZE15V22RD;4ZE15V22RD;Cefprozil monohydrate impurity F [EP];(6R,7R)-7-Amino-8-oxo-3-((1E)-prop-1-enyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;(6R,7R)-7-amino-8-oxo-3-[(E)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-Amino-8-oxo-3-((1E)-prop-1-enyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, (6R,7R)-;DE(2-amino-2-(4-hydroxyphenyl)acetyl)cefprozil, (E)-;7-APRA;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-(1E)-1-propen-1-yl-, (6R,7R)-;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-(1E)-1-propenyl-, (6R,7R)-;(6R,7R)-7-Amino-8-oxo-3-[(1E)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-amino-8-oxo-3-(1-propenyl)-, (6R-(3(E),6alpha,7beta))-;7 Apra;Cefprozil EP Impurity D;Cefprozil EP Impurity F;(6R,7R)-7-amino-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbo;DTXSID20148332;ZYLDQHILNOZKIF-DHLUJLSBSA-N;AMY27770;BCP10063;AKOS015964988;AKOS025149355;AC-1879;AS-15055;CEFPROZIL IMPURITY F [EP IMPURITY];H11004;A892112;CEFPROZIL MONOHYDRATE IMPURITY F [EP IMPURITY];Q27260710;Cefprozil intermediate;Cefprozil main-ring;(6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid;5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-AMINO-8-OXO-3-(1-PROPENYL)-, (6R-(3(E),6.ALPHA.,7.BETA.))-

Suppliers and Price of (6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of (6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Chemical Property:

XLogP3:-2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:240.05686342
Heavy Atom Count:16
Complexity:416

Purity/Quality:: > 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC=CC1=C(N2C(C(C2=O)N)SC1)C(=O)O
Isomeric SMILES:C/C=C/C1=C(N2[C@@H]([C@@H](C2=O)N)SC1)C(=O)O

Technology Process of (6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

There total 3 articles about (6R,7R)-7-Amino-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

: 10416-59-8
N,O-bis-(trimethylsilyl)-acetamide

: C₈H₈N₂O₄S

: 106447-44-3
cis-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid

: 107937-01-9
trans-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid

Guidance literature:: N,O-bis-(trimethylsilyl)-acetamide; C₈H₈N₂O₄S; In dichloromethane; at 20 ℃; for 3h;

With ethyltriphenylphosphonium bromide; In dichloromethane; at 0 - 5 ℃; for 3h; Temperature;

Reference yield:

: 190790-85-3
(7R,8R)-7-phenylacetamido-3-[propen-1-yl]-3-cephem-4-carboxylic acid p-methoxybenzyl ester

: 106447-44-3
cis-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid

: 107937-01-9
trans-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid

Guidance literature:: With pyridine; phosphorus pentachloride; In dichloromethane; at 20 ℃; for 0.5h;

(7R,8R)-7-phenylacetamido-3-[propen-1-yl]-3-cephem-4-carboxylic acid p-methoxybenzyl ester; In dichloromethane; for 2h;

With propylene glycol; water; ortho-cresol; more than 3 stages;

Reference yield:

: (6R,7R)-7-isopropylideneammonio-3-[(Z)-propen-1-yl]-3-cephem-4-carboxylic acid hydrochloride

: (6R,7R)-7-isopropylideneammonio-3-[(E)-propen-1-yl]-3-cephem-4-carboxylic acid hydrochloride

: 106447-44-3
cis-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid

: 107937-01-9
trans-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid

Guidance literature:: (6R,7R)-7-isopropylideneammonio-3-[(Z)-propen-1-yl]-3-cephem-4-carboxylic acid hydrochloride; (6R,7R)-7-isopropylideneammonio-3-[(E)-propen-1-yl]-3-cephem-4-carboxylic acid hydrochloride; With pyrographite; In water; for 0.25h; pH=8 - 8.5;

With hydrogenchloride; In water; at 20 ℃; for 0.5h; pH=3 - 3.5;