4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide

Base Information

• Chemical Name: 4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide
• CAS No.: 1373027-55-4
• Molecular Formula: C₃₂H₂₇N₃O₂S₂
• Molecular Weight: 549.717
• Mol file: 1373027-55-4.mol

Synonyms:

Chemical Property of 4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide

There total 3 articles about 4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-(phenyl)-3-thiazolidine-carboxamide (1373027-25-8) + benzaldehyde (100-52-7) → 4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide (1373027-55-4)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 - 90 ℃; for 7h;

DOI:10.2298/JSC100924152S

Reference yield:

10-(3-chloropropyl)-10H-phenothiazine (5909-59-1) → 4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide (1373027-55-4)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 4 h / 20 °C

2: acetic acid / ethanol / 5.3 h / 20 - 90 °C / Reflux

3: zinc(II) chloride / methanol / 8 h / 20 - 90 °C

4: sodium ethanolate / ethanol / 7 h / 20 - 90 °C

With sodium ethanolate; acetic acid; zinc(II) chloride; In methanol; ethanol; 4: Knoevenagel condensation;

DOI:10.2298/JSC100924152S

Reference yield:

10H-phenothiazine (92-84-2) → 4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-phenyl-5-(phenylmethylidene)-3-thiazolidinecarboxamide (1373027-55-4)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 5 h / 20 °C

2: ethanol / 4 h / 20 °C

3: acetic acid / ethanol / 5.3 h / 20 - 90 °C / Reflux

4: zinc(II) chloride / methanol / 8 h / 20 - 90 °C

5: sodium ethanolate / ethanol / 7 h / 20 - 90 °C

With sodium ethanolate; acetic acid; zinc(II) chloride; In methanol; ethanol; 5: Knoevenagel condensation;

DOI:10.2298/JSC100924152S

upstream raw materials:

4-oxo-N-[3-(10H-phenothiazin-10-yl)propyl]-2-(phenyl)-3-thiazolidine-carboxamide

benzaldehyde

10H-phenothiazine

10-(3-chloropropyl)-10H-phenothiazine