GDP-fucose

Base Information

• Chemical Name: GDP-fucose
• CAS No.: 27461-48-9
• Molecular Formula: C₁₆H₂₅N₅O₁₅P₂
• Molecular Weight: 589.347
• Mol file: 27461-48-9.mol

Synonyms:

Chemical Property of GDP-fucose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GDP-fucose

There total 5 articles about GDP-fucose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C37H43N5O15P2 → guanosine 5’-diphospho-L-fucose (15839-70-0,15839-74-4,16597-51-6,18657-20-0,27180-10-5,27461-48-9,31701-20-9,55331-70-9,68509-82-0)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; Yield given; Ambient temperature;

DOI:10.1021/jo00106a007

Reference yield:

(3S,4R,5R,6S)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-ol (162118-38-9) → guanosine 5’-diphospho-L-fucose (15839-70-0,15839-74-4,16597-51-6,18657-20-0,27180-10-5,27461-48-9,31701-20-9,55331-70-9,68509-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (COBr)2 / CH₂Cl₂; dimethylformamide / 0.5 h / Ambient temperature

2: CH₂Cl₂ / Ambient temperature

3: H₂ / 20percent Pd(OH)2/C / methanol / Ambient temperature

With Oxalyl bromide; hydrogen; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00106a007

Reference yield:

perbenzyl fucosyl bromide (76946-04-8) → guanosine 5’-diphospho-L-fucose (15839-70-0,15839-74-4,16597-51-6,18657-20-0,27180-10-5,27461-48-9,31701-20-9,55331-70-9,68509-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / Ambient temperature

2: H₂ / 20percent Pd(OH)2/C / methanol / Ambient temperature

With hydrogen; palladium dihydroxide; In methanol; dichloromethane;

DOI:10.1021/jo00106a007

upstream raw materials:

(3S,4R,5R,6S)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-ol

perbenzyl fucosyl bromide

6-deoxy-L-galactose

Guanosine 5'-triphosphate

Downstream raw materials:

2,2-bis(benzyloxymethyl)-1,3-bis-[O-β-D-galactopyranosyl-(1->4)-(2-amino-2-deoxy-3-O-α-L-fucopyranosyl-β-D-glucopyranosyloxy)]-propane butane 1N,4N'-dioyl amide