N-(2-nitrobenzoyl)leucine N,N-diethylamide

Base Information

• Chemical Name: N-(2-nitrobenzoyl)leucine N,N-diethylamide
• CAS No.: 1404467-30-6
• Molecular Formula: C₁₇H₂₅N₃O₄
• Molecular Weight: 335.403
• Mol file: 1404467-30-6.mol

Synonyms:

Chemical Property of N-(2-nitrobenzoyl)leucine N,N-diethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-nitrobenzoyl)leucine N,N-diethylamide

There total 2 articles about N-(2-nitrobenzoyl)leucine N,N-diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

N-(2-nitrobenzoyl)leucine (24919-33-3) + diethylamine (109-89-7) → N-(2-nitrobenzoyl)leucine N,N-diethylamide (1404467-30-6)

Guidance literature:

N-(2-nitrobenzoyl)leucine; With diisopropyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

diethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201202253

Reference yield:

LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) + 2-nitrobenzyl chloride (610-14-0) → N-(2-nitrobenzoyl)leucine N,N-diethylamide (1404467-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methyloxirane / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: diisopropyl-carbodiimide / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With methyloxirane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201202253

upstream raw materials:

N-(2-nitrobenzoyl)leucine

diethylamine

LEUCINE

2-nitrobenzyl chloride