Technology Process of 1,6-anhydro-3-O-benzyl-2-deoxy-2-C-methyl-4-methylene-β-D-ribo-hexopyranose
There total 7 articles about 1,6-anhydro-3-O-benzyl-2-deoxy-2-C-methyl-4-methylene-β-D-ribo-hexopyranose which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodium hydride / 1.) DMF, 20 deg C, 1 h; 2.) DMF, 20 deg C, 0.5 h
2: 1.) potassium tert-butoxide; 2.) mercury(II) oxide, mercury(II) chloride / 1.) methyl sulfoxide, 100 deg C, 1 h; 2.) acetone, water
3: 98.5 percent / methyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -60 °C
4: 89 percent / sodium methoxide / methanol / 1 h / 20 °C
5: 1.) butyl-lithium / 1.) hexane, benzene, 15 min; 2.) hexane, benzene, reflux, 10 min
With
n-butyllithium; oxalyl dichloride; potassium tert-butylate; sodium methylate; sodium hydride; dimethyl sulfoxide; mercury dichloride; mercury(II) oxide;
In
methanol; dichloromethane;
DOI:10.1016/0008-6215(85)85189-2
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) sodium hydride / 1.) DMF, 20 deg C, 1 h; 2.) DMF, 20 deg C, 0.5 h
2: 1.) potassium tert-butoxide; 2.) mercury(II) oxide, mercury(II) chloride / 1.) methyl sulfoxide, 100 deg C, 1 h; 2.) acetone, water
3: 98.5 percent / methyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -60 °C
4: 89 percent / sodium methoxide / methanol / 1 h / 20 °C
5: 1.) butyl-lithium / 1.) hexane, benzene, 15 min; 2.) hexane, benzene, reflux, 10 min
With
n-butyllithium; oxalyl dichloride; potassium tert-butylate; sodium methylate; sodium hydride; dimethyl sulfoxide; mercury dichloride; mercury(II) oxide;
In
methanol; dichloromethane;
DOI:10.1016/0008-6215(85)85189-2
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / diethyl ether / 12 h / Heating
2: 1.) sodium hydride / 1.) DMF, 20 deg C, 1 h; 2.) DMF, 20 deg C, 0.5 h
3: 1.) potassium tert-butoxide; 2.) mercury(II) oxide, mercury(II) chloride / 1.) methyl sulfoxide, 100 deg C, 1 h; 2.) acetone, water
4: 98.5 percent / methyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.25 h / -60 °C
5: 89 percent / sodium methoxide / methanol / 1 h / 20 °C
6: 1.) butyl-lithium / 1.) hexane, benzene, 15 min; 2.) hexane, benzene, reflux, 10 min
With
n-butyllithium; oxalyl dichloride; potassium tert-butylate; sodium methylate; sodium hydride; dimethyl sulfoxide; mercury dichloride; mercury(II) oxide;
In
methanol; diethyl ether; dichloromethane;
DOI:10.1016/0008-6215(85)85189-2
