91510-63-3Relevant academic research and scientific papers
A facile synthesis of Cerny epoxides and selectively blocked derivatives of 2-azido-2-deoxy-β-D-glucopyranose
Xue, Jie,Guo, Zhongwu
, p. 6487 - 6489 (2007/10/03)
1,6:2,3-Dianhydro-β-D-glucopyranose and its 3-alkylated derivatives were prepared from D-glucal in one pot with overall isolated yields of 60-70%, and these Cerny epoxides were further conveniently converted to selectively blocked 2-azido-2-deoxy-β-D-glucopyranose derivatives by azido opening of the epoxide ring.
Synthesis and biological activity of oligomer-model compounds containing units of a key platelet-binding disaccharide of heparin
Koshida, Shuhei,Suda, Yasuo,Fukui, Yasuhiro,Ormsby, Julie,Sobel, Michael,Kusumoto, Shoichi
, p. 5725 - 5728 (2007/10/03)
A key disaccharide unit in heparin, O-(2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranosyl)-(1→4)-2-O-sulfo-α-L-idop yranosyluronic acid, was previously found to be responsible for the binding interaction of heparin to platelets. A clustering effect to enhance the binding was found to be dependent on the number and frequency of the disaccharide units in a heparin molecule. To systematically examine the clustering effect, three oligomer-model compounds containing two or three units of the disaccharide were synthesized. These compounds inhibited 3H-labelled heparin binding to human platelets more strongly than a compound containing only one unit of the disaccharide.
Opening of levoglucosane derived epoxides with oxygen, nitrogen and sulfur nucleophiles
Brill, Wolfgang K.-D.,Tirefort, Dominique
, p. 787 - 790 (2007/10/03)
A variety of nucleophiles were employed to open levoglucosane derived epoxides.
