Technology Process of 7-(4-Fluoro-phenyl)-octahydro-2,5-methano-inden-7-ol
There total 1 articles about 7-(4-Fluoro-phenyl)-octahydro-2,5-methano-inden-7-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 0.5 h / Heating; reflux with 98percent HCOOH
2: 67 percent / 1 N HCl / acetone / 2 h / Heating
3: 94 percent / Jones reagent (CrO3) / acetone; H2O / 3.5 h / 15 °C
4: 97 percent / 50 percent NaH in paraffin / tetrahydrofuran / 0.17 h / 25 °C
5: 98 percent / H2 / 10 percent Pd/C / ethanol / 30 h / 25 °C / 2068.6 Torr
With
chromium(VI) oxide; hydrogenchloride; hydrogen; sodium hydride;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; water; acetone;
DOI:10.1016/S0040-4020(01)90332-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 0.5 h / Heating; reflux with 98percent HCOOH
2: 67 percent / 1 N HCl / acetone / 2 h / Heating
3: 94 percent / Jones reagent (CrO3) / acetone; H2O / 3.5 h / 15 °C
4: 97 percent / 50 percent NaH in paraffin / tetrahydrofuran / 0.17 h / 25 °C
5: 98 percent / H2 / 10 percent Pd/C / ethanol / 30 h / 25 °C / 2068.6 Torr
6: 83 percent / 30 percent H2O2, 0.2 M aq. NaOH / methanol; dimethylsulfoxide / 12 h / 50 - 55 °C
With
chromium(VI) oxide; hydrogenchloride; sodium hydroxide; hydrogen; dihydrogen peroxide; sodium hydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; acetone;
DOI:10.1016/S0040-4020(01)90332-1
