N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine

Base Information

Chemical Name:N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine
CAS No.:288250-03-3
Molecular Formula:C₂₅H₂₄FN₅O₄
Molecular Weight:477.495
Hs Code.:

Synonyms:

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Chemical Property of N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine

Chemical Property:

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Technology Process of N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine

There total 12 articles about N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₂FN₅O₄Si

: 288250-03-3
N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 80 ℃; for 1h;

Reference yield:

: 16588-15-1
2-chloro-5-nitro-benzamide

: 288250-03-3
N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine

Guidance literature:: Multi-step reaction with 7 steps

1: benzenesulfonyl chloride / DMF (N,N-dimethyl-formamide); toluene / 3 h / 20 - 145 °C

2: ethanol / 1 h / Heating / reflux

3: pyridine; toluene / 3 h / 20 °C / Ice cooling

4: iron; ammonium chloride / ethanol; water / 0.83 h / 65 °C / Heating / reflux

5: pyridine / 1 h / 20 °C

6: sodium hydride / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C / Cooling with ice

7: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 80 °C

With tetrabutyl ammonium fluoride; iron; sodium hydride; ammonium chloride; benzenesulfonyl chloride; In tetrahydrofuran; pyridine; DMF (N,N-dimethyl-formamide); ethanol; water; toluene; acetonitrile;

Reference yield:

: 2516-96-3
2-chloro-5-nitrobenzoic acid

: 288250-03-3
N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-3-methylpyrazol-4-ylcarbonyl]glycine

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / DMF (N,N-dimethyl-formamide); toluene / 3 h / 20 °C / Heating / reflux

1.2: Ice cooling

2.1: benzenesulfonyl chloride / DMF (N,N-dimethyl-formamide); toluene / 3 h / 20 - 145 °C

3.1: ethanol / 1 h / Heating / reflux

4.1: pyridine; toluene / 3 h / 20 °C / Ice cooling

5.1: iron; ammonium chloride / ethanol; water / 0.83 h / 65 °C / Heating / reflux

6.1: pyridine / 1 h / 20 °C

7.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C / Cooling with ice

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 80 °C

With thionyl chloride; tetrabutyl ammonium fluoride; iron; sodium hydride; ammonium chloride; benzenesulfonyl chloride; In tetrahydrofuran; pyridine; DMF (N,N-dimethyl-formamide); ethanol; water; toluene; acetonitrile;