4-(1H-Pyrazol-1-yl)-piperidine 2HCl

Base Information

• Chemical Name: 4-(1H-Pyrazol-1-yl)-piperidine 2HCl
• CAS No.: 1181458-83-2
• Molecular Formula: C₈H₁₃N₃*ClH
• Molecular Weight: 187.672
• Hs Code.: 2933399990
• Mol file: 1181458-83-2.mol

Synonyms:

Chemical Property of 4-(1H-Pyrazol-1-yl)-piperidine 2HCl

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4-(1H-Pyrazol-1-yl)piperidineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1H-Pyrazol-1-yl)-piperidine 2HCl

There total 2 articles about 4-(1H-Pyrazol-1-yl)-piperidine 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1H-pyrazol-1-yl)pyridine hydrochloride (1357589-48-0) → 4-(1H-pyrazol-1-yl)piperidine hydrochloride (690261-87-1,1181458-83-2) + piperidine hydrochloride (6091-44-7)

Guidance literature:

With 5% rhodium-on-charcoal; hydrogen; In water; at 50 ℃; for 16h; under 150 Torr;

DOI:10.1016/j.tetlet.2011.12.044

Reference yield:

4-chlorpyridine hydrochloride (7379-35-3) → 4-(1H-pyrazol-1-yl)piperidine hydrochloride (690261-87-1,1181458-83-2) + piperidine hydrochloride (6091-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 24 h / Inert atmosphere; Reflux; Large scale reaction

1.2: 0.5 h / 20 - 25 °C / Inert atmosphere; Large scale reaction

2.1: 5% rhodium-on-charcoal; hydrogen / water / 16 h / 50 °C / 150 Torr

With 5% rhodium-on-charcoal; hydrogen; In water; acetonitrile;

DOI:10.1016/j.tetlet.2011.12.044

Reference yield: 41.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(1H-pyrazol-1-yl)piperidine hydrochloride (1181458-83-2) → 4-pyrazol-1-yl-piperidine-1-carboxylic acid tert-butyl ester (1269429-29-9)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

upstream raw materials:

4-(1H-pyrazol-1-yl)pyridine hydrochloride

4-chlorpyridine hydrochloride

Downstream raw materials:

4-pyrazol-1-yl-piperidine-1-carboxylic acid tert-butyl ester

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