(5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one

Base Information

Chemical Name:(5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one
CAS No.:1429386-07-1
Molecular Formula:C₂₅H₂₉Cl₂NO₂S
Molecular Weight:478.483
Hs Code.:

Synonyms:

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Chemical Property of (5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one

Chemical Property:

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Technology Process of (5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one

There total 10 articles about (5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride

: 1429386-07-1
(5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 25 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.2: 25 °C / Inert atmosphere

5.1: lithium triethylborohydride / tetrahydrofuran / Inert atmosphere

6.1: cyanomethyl tributylphosphorane / toluene / 12 h / 110 °C / Inert atmosphere

With cyanomethyl tributylphosphorane; sodium hydride; lithium triethylborohydride; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm401767k

Reference yield:

: C₂₀H₂₅Cl₂NO₃Si

: 1429386-07-1
(5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; zinc / water / Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 25 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 25 °C / Inert atmosphere

6.1: lithium triethylborohydride / tetrahydrofuran / Inert atmosphere

7.1: cyanomethyl tributylphosphorane / toluene / 12 h / 110 °C / Inert atmosphere

With hydrogenchloride; cyanomethyl tributylphosphorane; sodium hydride; lithium triethylborohydride; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm401767k

Reference yield:

: 1429382-53-5
(1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol

: 1429386-07-1
(5R,6R)-4-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(3-chlorophenyl)-5-(4-chlorophenyl)morpholin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 25 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 25 °C / Inert atmosphere

4.1: lithium triethylborohydride / tetrahydrofuran / Inert atmosphere

5.1: cyanomethyl tributylphosphorane / toluene / 12 h / 110 °C / Inert atmosphere

With cyanomethyl tributylphosphorane; sodium hydride; lithium triethylborohydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm401767k