(R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate
CAS No.:1342299-93-7
Molecular Formula:C₃₈H₄₈N₄O₆S
Molecular Weight:688.888
Hs Code.:

(R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate

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Technology Process of (R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate

There total 15 articles about (R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1342299-93-7
(R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

2.1: N,N-diethylaniline / 15 h / 200 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1.75 h / 60 °C

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 15 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 13.5 h / 20 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 43 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20.5 h / 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2.25 h / 50 °C

8.2: pH 2

9.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20.5 h / 20 °C

With water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium hydroxide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 111060-52-7
(S)-2-(dibenzylamino)-3-phenylpropan-1-ol

: 1342299-93-7
(R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 0 °C

2.1: sec.-butyllithium; (-)-sparteine / diethyl ether / 2 h / -78 °C

2.2: 0.33 h / Cooling

2.3: 20 °C / Cooling

3.1: hydrogen / palladium(II) hydroxide / methanol / 17 h

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20.5 h / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2.25 h / 50 °C

5.2: pH 2

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20.5 h / 20 °C

With water; hydrogen; sec.-butyllithium; sulfur trioxide pyridine complex; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; (-)-sparteine; palladium(II) hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 869527-43-5
tert-butyl (R)-2-((1S,2S)-2-dibenzylamino-1-hydroxy-3-phenyl-propyl)-pyrrolidine-1-carboxylate

: 1342299-93-7
(R)-tert-butyl 2-((1S,2S)-1-hydroxy-2-(6-((R)-2-(4-methylthiazol-2-yl)pyrrolidine-1-carbonyl)-2,3,4,5-tetrahydrobenzo[b]oxepine-8-carboxamido)-3-phenylpropyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium(II) hydroxide / methanol / 17 h

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20.5 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2.25 h / 50 °C

3.2: pH 2

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20.5 h / 20 °C

With water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium(II) hydroxide; In tetrahydrofuran; methanol; dichloromethane;