101349-71-7

Basic information

• Product Name: 4-CHLORO-3-METHYLBENZALDEHYDE
• Synonyms: 4-CHLORO-3-METHYLBENZALDEHYDE;Benzaldehyde, 4-chloro-3-Methyl-
• CAS NO: 101349-71-7
• Molecular Formula: C₈H₇ClO
• Molecular Weight: 154.59
• Mol File: 101349-71-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 27-28°C
• Boiling Point: 115°C 27mm
• Flash Point: 105.6 °C
• Appearance: /
• Density: 1.195 g/cm³
• Vapor Pressure: 0.0542mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-CHLORO-3-METHYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3-METHYLBENZALDEHYDE(101349-71-7)
• EPA Substance Registry System: 4-CHLORO-3-METHYLBENZALDEHYDE(101349-71-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-51-41-37/38
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 101349-71-7(Hazardous Substances Data)

Usage

Uses

4-Chloro-3-methylbenzaldehyde is a reactant used in the preparation of pyrrolidine Ureas as C-C chemokine receptor 1 (CCR1) antagonists.

InChI:InChI=1/C8H7ClO/c1-6-4-7(5-10)2-3-8(6)9/h2-5H,1H3

Upstream product

• 54932-72-8 2-chloro-5-bromotoluene 
• 68-12-2 N,N-dimethyl-formamide 
• 201230-82-2 carbon monoxide 
• 95-49-8 2-methylchlorobenzene 
• 4403-61-6 2-methyl-2-butene nitrile 
• 95-66-9 2,4-dimethylchlorobenzene 
• 100-97-0 hexamethylenetetramine 
• 117890-58-1 4-(bromomethyl)-1-chloro-2-methylbenzene 

Downstream Products

• 7697-29-2 4-chloro-3-methylbenzoic acid 
• 1027222-59-8 [1-(4-Chloro-3-methyl-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine 
• 1026380-36-8 2-(4-Chloro-3-methyl-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol 
• 1449691-99-9 N-[(4-chloro-3-methyl-phenyl)-(toluene-4-sulfonyl)methyl]formamide 
• 1449692-01-6 5-(4-chloro-3-methyl-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 1449692-02-7 5-(4-chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-pyrrole-3-carboxylic acid ethyl ester 
• 1480377-53-4 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-1H-pyrrole-3-carboxylic acid 
• 1449692-03-8 [5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrol-3-yl]methanol 
• 1449692-04-9 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-1H-pyrrole-3-carbaldehyde 
• 1449692-07-2 dimethyl (2-[5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)-methyl]-1H-pyrrol-3-yl]-2-hydroxy-1-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethyl)phosphonate 
• 1449691-92-2 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-3-[(E)-2-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]ethenyl]-1H-pyrrole 

Relevant articles and documents

Heterocyclic compound with Wnt signal path inhibitory activity and application thereof

The invention provides a heterocyclic compound with Wnt signal path inhibitory activity. The heterocyclic compound and chemically acceptable salt, isotope, isomer and a crystal structure thereof are provided with a structure shown as the general formula I (see the formula in the description). The invention further provides application of the heterocyclic compound with the Wnt signal path inhibitory activity. The heterocyclic compound with the Wnt signal path inhibitory activity serves as effective antagonist of a Wnt signal path, and can be used for treating or preventing diseases caused by abnormity of the Wnt signal path.

NOVEL IMIDAZOLES WITH ANTI-INFLAMMATORY ACTIVITY

Compounds of formula I wherein: one of X or Y represents N and the other represents C; R1 represents hydrogen, methyl, halogen, cyano, nitro, -CHO, -COCH3 or -COOR4; R2 represents optionally-substituted aryl or heteroaryl; R3 represents C1-8 alkyl, C1-8 haloalkyl or -NR4R6; R4 represents hydrogen, C1-8 alkyl or arylC0-8 alkyl; R6 represents hydrogen, C1-8 alkyl, arylC1-8 alkyl, -COR8 or -COOR8; R8 represents C1-8 alkyl or C1-8 haloalkyl; aryl in the above definitions represents phenyl or naphthyl; and heteroaryl in the above definitions represents pyridine, pyrazine, pyrimidine or pyridazine, which can be optionally fused to a benzene ring. These compounds are useful as cyclooxygenase-2 inhibitors.